妊娠年龄较小的婴儿死性肠球炎的危险因素:一个匹配的病例对照研究
Xiang-Ping Ding1, Xiang-Wen Hu1, Shi Chen2
1Department of Neonatology, Jiangxi Hospital Affiliated to Children's Hospital of Chongqing Medical University, Nanchang, 330103, People's Republic of China.
Scientific reports
|August 17, 2024
概括
败血症和贫血增加了怀孕年龄 (SGA) 婴儿小的死角性肠球炎 (NEC) 的风险. 益生菌的使用可能会在这些脆弱的新生儿中防止NEC.
科学领域:
- 新生儿科学 新生儿科学
- 儿科胃肠病学 儿科胃肠病学
- 围产儿医学 围产儿医学
背景情况:
- 死性肠球炎 (NEC) 是一种严重的疾病,影响新生儿.
- 对于妊娠年龄 (SGA) 较小的婴儿特别容易受到NEC的影响.
- 有限的研究存在于NEC风险因素,特别是在SGA婴儿.
研究的目的:
- 识别妊娠年龄 (SGA) 超小的新生儿中NEC的独立风险因素.
- 研究预防性益生菌在SGA婴儿中对NEC的潜在保护作用.
主要方法:
- 对2008年1月至2022年12月期间入院的SGA新生儿进行回顾性队列研究.
- 将被诊断为NEC (贝尔阶段≥II) 的婴儿与没有NEC的匹配对照进行比较.
- 单变量和逻辑回归分析以确定风险因素.
主要成果:
- 在2,912名SGA婴儿中,有150名 (5.15%) 患有NEC.
- 败血症 (OR 2.399) 和贫血症 (OR 2.214) 被确定为NEC的重要危险因素.
- 预防性益生菌的使用显示出保护作用 (OR 0.492).
结论:
- 败血症和贫血是独立的风险因素,有助于SGA婴儿的NEC发病率.
- 预防性益生菌可以降低这种高风险人群中NEC的风险.
- 针对败血症和贫血的有针对性的干预措施,以及益生菌的使用,可以改善SGA新生儿的NEC结果.
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