在暴露于Pb,Cr,Cu和Zn的儿童中,与红细胞相关的异常参数
Zhuxia Zhang1, Bo Xie1, Qi Zhong1,2
1Laboratory of Environmental Medicine and Developmental Toxicology, Guangdong Key Laboratory of Environmental Pollution and Health, College of Environment and Climate, Jinan University, Guangzhou, 511443, Guangdong, China.
这项研究表明,对铜,,和等重金属的联合暴露与儿童的贫血有关. 这些金属之间的相互作用显著影响红细胞参数,这表明金属诱导的贫血中存在复杂的机制.
科学领域:
- 环境健康 环境健康
- 儿科血液学 儿科血液学
- 毒理学 毒理学 毒理学
背景情况:
- 单次重金属暴露与贫血之间的联系是已知的,但对儿童联合暴露的证据有限.
- 儿童特别容易受到环境毒素的影响,因为他们的生理系统正在发育.
研究的目的:
- 调查多种重金属化物和儿童贫血相关参数的联合暴露之间的关联.
- 探索不同重金属之间的相互作用及其对血液学指数的影响.
主要方法:
- 招募了266名年龄在3至7岁的儿童,他们来自中国的州.
- 使用诱导合等离子体质谱法 (ICP-MS) 测量了血液中的重金属度.
- 使用自动化血液学分析仪评估了包括血红蛋白,MCH,MCV,MCHC在内的血液学参数,并使用斯皮尔曼相关性,多重线性回归和贝叶斯内核机器回归 (BKMR) 分析了数据.
主要成果:
- 红细胞参数与铜 (Cu) 和Cu/Zn比率呈负相关性,与 (Cr), (Ni), (Zn) 和 (Se) 呈正相关性.
- 血中的Cu水平与血红蛋白 (HGB),平均体质血红蛋白 (MCH),平均体质体积 (MCV) 和平均体质血红蛋白度 (MCHC) 有负相关性.
- BKMR模型表明,Cu,Zn, (Pb) 和Cr与MCH和MCV的联合暴露之间存在负相关性,Cu和Zn,Pb和Zn,Cr和Zn之间有显著的相互作用.
结论:
- 对多种重金属,特别是Cu,Zn,Pb和Cr的联合暴露与儿童的MCH和MCV降低有关.
- 氧化和/或抗氧化反应可能在金属化物引起的贫血的发展中起作用.
- 对多种重金属的共同暴露的相互关系和机制的进一步研究对于了解贫血风险至关重要.
更多相关视频
13:04Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells
Published on: May 16, 2019
08:46Dose Uptake of Platinum- and Ruthenium-based Compound Exposure in Zebrafish by Inductively Coupled Plasma Mass Spectrometry with Broader Applications
Published on: April 21, 2022
相关概念视频
Disorders of Erythrocytes
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
Factors Affecting Erythropoiesis
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
Erythropoiesis
Rh Blood Group
Disorders of Hemostasis
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
