老年患者的虚弱和低蛋白血症之间的关联:元分析和系统审查
Linxue Zhang1,2, Pingping Yang1,2, Furong Yin1,2
1Nursing Department, Affiliated Hospital of Zunyi Medical University, Zunyi, 563000, China.
BMC geriatrics
|August 17, 2024
概括
虚弱与老年人中蛋白质水平较低有关,特别是在住院患者中. 这一元分析证实了各种患者群体之间的关联,表明白补充剂的潜在益处.
科学领域:
- 老年学是一门学科.
- 临床营养学 临床营养学
- 内部医学 内部医学
背景情况:
- 虚弱和低蛋白血 (低血蛋白水平) 是老年人群中普遍存在的疾病.
- 虽然脆弱性和低蛋白血症之间存在相关性,但在特定的患者群体 (如住院患者和社区老年人) 中,它们之间的关系需要进一步澄清.
研究的目的:
- 在不同临床环境中进行元分析,评估老年人脆弱性 (包括脆弱性前期) 和低蛋白质血症之间的关联.
主要方法:
- 在主要数据库 (PubMed,Embase,Medline,Web of Science,Cochrane,Wanfang,CNKI) 进行了系统的文献搜索,截至2024年4月.
- 包括的研究集中在患有脆弱或脆弱前期和低蛋白血症的老年人身上.
- 研究质量使用纽卡斯尔-太华尺度和医疗保健研究和质量尺度机构来评估.
主要成果:
- 分析包括22项研究,涉及90,351名参与者.
- 在虚弱或虚弱前和低蛋白血症之间发现了显著的关联 (OR=2.37,95% CI: 1.47,3.83;OR=1.62,95% CI: 1.23,2.15).
- 与手术患者相比,住院/危急病患者 (OR=3.75,95% CI: 2.36,5.96) 和老年社区居民 (OR=2.30,95% CI: 1.18,4.49) 的相关性更强. 在严重的脆弱性和低/中等脆弱性之间没有观察到高蛋白质血风险的显著差异.
结论:
- 虚弱与手术患者,住院老年人和社区老年人的低蛋白质血症显著相关.
- 未来的研究应该调查白蛋白补充剂对预防或减轻脆弱性及其相关结果的潜在益处.
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