相关实验视频

Updated: Jun 16, 2025

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Published on: September 26, 2019

在儿童湿疹中捕获和报告局部治疗使用:在湿疹试验中收集数据的教训

Katherine E Memory¹, Stephanie J MacNeill², Kim S Thomas³

¹Population Health Sciences Institute, Bristol Medical School, University of Bristol, Bristol, UK.

Clinical and experimental dermatology

|August 18, 2024

概括

第二个问卷版本改善了儿童湿疹试验中的软化剂使用数据收集. 这种版本,报告每周一天的使用情况,比第一个软化剂使用版本的完成率更高,这对于准确的局部治疗报告至关重要.

科学领域:

皮肤病学皮肤病学
临床试验方法论临床试验方法论
儿科医生湿疹管理管理

背景情况:

局部治疗,如软化剂和局部皮质类固醇 (TCS) 对于管理湿疹爆发至关重要.
目前用于记录局部治疗使用的临床试验方法不一致,缺乏标准化的报告.
需要就研究中捕获和总结热点治疗数据的最佳策略达成共识.

研究的目的:

评估和比较不同的方法来捕获和报告儿科湿疹临床试验中的局部治疗使用情况.
确定最有效的问卷设计,以收集准确的软化剂和局部皮质类固醇 (TCS) 使用数据.
为在未来的湿疹研究中收集局部治疗数据提供最佳实践信息.

主要方法:

从BEE试验中对450名参与者的二次分析.
两种用于记录局部治疗使用的问卷版本的比较:版本1 (每日报告) 和版本2 (每周一天报告).
对16周的软化剂和TCS的问卷填写率和数据完整性的评估,其中版本2接受了更严格的测试.

主要成果:

随着时间的推移,缓解剂和局部皮质类固醇 (TCS) 使用的问卷填写量都下降了.
与第一个版本相比,第二个调查问卷版本的软化剂使用完成率显著更高 (87.9%与33.5%相比).
在两种问卷版本中,TCS使用的完成率在两种问卷版本之间都是相似的,这表明两种治疗类型的数据采集都很稳定.

结论:

第二个问卷版本,捕捉了每周一天的使用情况,改善了儿科湿疹试验中软化剂使用数据的完整性.
设计问卷需要平衡细节和复杂性,特别是在作为次要结果收集数据时.
在设计和报告局部治疗使用数据收集方法时,未来的湿疹研究应该仔细考虑试验目标.

更多相关视频

Author Spotlight: Exploring ShiDuGao's Multi-Target Approach in Anus Eczema Treatment

Author Spotlight: Exploring ShiDuGao's Multi-Target Approach in Anus Eczema Treatment

Published on: January 12, 2024

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

相关概念视频

Clinical Trials

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...

Data Collection I

Data Collection I

Data collection gathers information needed to make accurate judgments about a patient's present condition. During a health history interview, subjective data is collected from the patient, their caregivers, or family members, and objective data is collected through observations and physical assessment. Patients are the primary source of subjective data. Thus information gathered from patients through interviews, observations, and physical examination is primary data. Secondary sources of...

Clinical Applications of Epidermal Stem Cells

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...