围边缘参与直肠癌的模式决定了其对结果的影响:基于人口的研究
Niek Hugen1, Quirinus J M Voorham2, Geerard L Beets3
1Rijnstate, Department of Surgery, Arnhem, the Netherlands; Radboud University Medical Center, Department of Surgery, Nijmegen, the Netherlands.
概括
围切除边缘 (CRM) 参与直肠癌的性质会影响复发和存活率. 在CRM中淋巴结转移的风险低于初级瘤入侵或多重因素.
科学领域:
- 在瘤学瘤学.
- 手术病理学手术病理学
- 癌症研究 癌症研究
背景情况:
- 不同类型的环切除边缘 (CRM) 参与直肠癌的临床意义尚不清楚.
- 局部发达的直肠癌需要精确的预后指标来规划治疗.
研究的目的:
- 调查CRM参与不同方式在局部晚期直肠癌患者的临床影响.
- 分析CRM参与性质和患者结果之间的关联,包括复发和整体存活率.
主要方法:
- 分析了2014年至2020年间诊断的全国3020名第三阶段直肠癌患者的队列.
- 关于CRM参与的组织病理学数据 (初级瘤入侵,淋巴结转移,瘤沉积,多种因素) 与复发和整体存活 (OS) 相相关.
主要成果:
- 12.4%的患者有阳性CRM,最常见的是由于原发性瘤侵袭 (63.2%).
- 当地复发率和远程转移率因CRM参与类型而异,淋巴结转移率最低.
- 由于原发性瘤入侵,瘤沉积和多个因素,但不是淋巴结转移的CRM参与,预测了糟糕的OS.
结论:
- 报告CRM参与直肠癌的具体性质在临床上至关重要.
- 通过淋巴结转移的CRM参与与初级瘤入侵或多个因素相比,复发,远程转移和OS的风险较低.
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