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Updated: Jun 16, 2025

Preparation of Naringenin Solution for In Vivo Application

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Published on: August 10, 2021

纳林因和诺基因组合通过减弱炎症反应来缓解耐素寄生虫诱导的疟疾病原体

Divya Bhatt¹, Kaveri R Washimkar², Saurabh Kumar¹

¹In vivo Testing facility, Bioprospection and Product Development Division, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, Uttar Pradesh 226015, India.

Phytomedicine : international journal of phytotherapy and phytopharmacology

|August 18, 2024

概括

纳林 (NGN) 是一种有前途的补充疗法,用于治疗耐克洛奎因疟疾. 与 (CQ) 结合,NGN有效降低了寄生虫水平和炎症,改善了疟疾模型中的生存率.

科学领域:

药理学药理学是指药理学的学科.
免疫学免疫学免疫学
寄生虫学的寄生虫学

背景情况:

耐药疟疾需要新的化疗药物,因为耐药性不断增加.
纳林 (NGN) 是一种黄糖化物,具有多种药理学活性.
单独或组合使用NGN的抗疟疾作用需要进一步研究.

研究的目的:

评估纳林 (NGN) 对抗抗抗性疟疾的疗效.
评估NGN与诺基因 (CQ) 结合的协同效应.
阐明NGN抗疟和抗炎作用的潜在机制.

主要方法:

评估了NGN对用血红素刺激的微质细胞的抗炎作用.
使用固定比率方法对抗Plasmodium K1菌株,确定NGN和CQ组合的抗质活性.
在感染Plasmodium yoelii的小鼠中评估了抗疟疾疗效,测量了寄生病,存活率和炎症标志物.
分析了NF-κB信号通路,细胞因子生产和肝脏和大脑组织病理.

主要成果:

NGN表现出显著的抗等离子体活性,与CQ结合时增强.
在体外和体内,NGN降低了促炎性细胞因子,调节了NF-κB信号传递.
在小鼠中,NGN治疗减少了寄生病和延长了生存时间,与CQ结合时效果更大.
NGN治疗恢复了肝脏和脑组织的正常状态,并减少了ICAM-1的表达,减轻了脑病理.

结论:

纳林 (NGN) 是一种潜在的辅助治疗药物,用于控制耐抗疟疾.
NGN的有效性源于其调节NF-κB介导炎症的能力.
NGN提供了与现有的抗疟疾药物联合治疗的有前途的策略.

关键词:

组合疗法是一种联合疗法.药物耐药性药物耐药性药物耐药性黄类化合物黄类炎症炎症是一种炎症.疟疾:疟疾是一种疾病.纳林丁 (Naringin) 是一个名为"纳林丁"的东西.

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