以NMR代谢学为指导的DNA甲基化死亡率预测因素
Daniele Bizzarri1, Marcel J T Reinders2, Lieke Kuiper3
1Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands; Leiden Computational Biology Center, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands; Delft Bioinformatics Lab, TU Delft, Delft, the Netherlands.
EBioMedicine
|August 18, 2024
概括
研究人员开发了血液代谢物的DNA甲基化预测剂,识别了与死亡相关的信号. 这些新的预测因素与现有的表观遗传钟相结合,为衰老和死亡风险提供了宝贵的见解.
科学领域:
- 生物标志物 生物标志物
- 基因组学就是基因组学.
- 代谢学 代谢学 代谢学
背景情况:
- H-NMR代谢和DNA甲基化是已知的与年龄相关的死亡生物标志物.
- 这些生物标志物提供了死亡率和脆弱性的独立信号.
研究的目的:
- 调查代谢死亡信号是否可以指导开发基于DNA甲基化的死亡预测器.
- 利用从人口研究中获取的多学科数据来构建新的死亡率预测指标.
主要方法:
- 培训了基于DNA甲基化的替代品,用于64种代谢分析物,使用来自5238个人的多omics数据.
- 使用DNA甲基化试验来重建特定的代谢分析物和已知的死亡风险评分 (MetaboHealth).
主要成果:
- 与炎症,液体平衡和脂质代谢相关的分析物的准确重建.
- 包括MetaboHealth在内的16种衍生代孕药显示出与死亡率有显著的独立关联.
- 从DNA甲基化数据准确地重建了MetaboHealth替代体.
结论:
- 从DNA甲基化中获得的代谢分析剂衍生的代用物显示出作为有价值的死亡率信号的潜力.
- 这些代孕物,当添加到像GrimAge这样的表观遗传钟时,可以提高死亡率的预测.
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