基于β-cyclopodextrin的含有不同电荷的鼻腔粉末的meloxicam的配方和研究
Patrícia Varga1, Anett Németh1, Scarlett Zeiringer2
1Institute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, Eötvös Street 6, Szeged 6720, Hungary.
概括
含有梅洛西卡姆单 (MXP) 的鼻腔药物输送粉末是使用充电式环极和聚乙醇 (PVA) 制成的. 阳性环氧增强了MXP的透,显示了鼻腔药物输送的前景.
科学领域:
- 制药技术 制药技术 制药技术
- 药物输送系统 药物输送系统
- 纳米技术 纳米技术
背景情况:
- 鼻腔药物输送为亲肠道和口腔途径提供了替代方案.
- 助剂对于增强鼻腔药物吸收和保留至关重要.
- 梅洛西卡姆单 (MXP) 是一个潜在的候选人用于鼻腔的管理.
研究的目的:
- 开发使用纳米喷雾干燥的梅洛西卡姆单 (MXP) 鼻粉.
- 评估中性,阳离子和阴离子β-环氧 (β-CDs) 和聚乙烯醇 (PVA) 对MXP鼻腔配方的影响.
- 研究助剂对粒子特性,粘附,药物释放和透的影响.
主要方法:
- 纳米喷雾干燥被用来生产MXP鼻粉.
- 描述包括激光散射,SEM,XRPD,DSC和FTIR.
- 使用人工膜和RPMI 2650细胞进行了粘合性,体外药物释放性和透性研究.
主要成果:
- 有无形MXP的球形粒子 (1.89-2.21μm) 已成功准备好.
- 在MXP和辅助剂之间观察到二次相互作用.
- 充电的β-CD配方表现出显著更高的粘附性;阳离子β-CD和PVA增强了MXP透.
结论:
- 纳米喷雾干燥对于生产具有理想性质的MXP鼻粉是有效的.
- 充电的β-CDs,特别是阳离子形式,显示出增强鼻腔药物透的潜力.
- 充电β-CD和PVA的组合为优化鼻腔药物输送系统提供了一个有希望的策略.
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