饮食中的牛奶脂增加体脂,调节小鼠的肠道透性,全身炎症和脂质代谢
Albert Lihong Zhou1, Robert E Ward1
1Nutrition, Dietetics, and Food Sciences, Utah State University, Logan, UT 84322.
Journal of dairy science
|August 18, 2024
概括
饮食中的牛奶化物 (GG) 降低了肠道透性,而牛奶脂 (MPL) 增加了体脂积累,并在饮食引起的肥胖中降低了肠道透性. 两者都没有影响全身炎症或胰岛素抵抗.
科学领域:
- 营养科学 营养科学
- 胃肠病学 胃肠病学
- 代谢研究研究 代谢研究
背景情况:
- 饮食诱导的肥胖 (DIO) 与肠道屏障功能和脂质代谢的改变有关.
- 牛奶的极性脂质,包括类脂质 (GG) 和类脂质 (MPL),是代谢健康的潜在调节剂.
- 了解它们在肥胖期间的具体影响对于有针对性的营养策略至关重要.
研究的目的:
- 调查饮食中的牛奶化物 (GG) 和牛奶脂 (MPL) 对饮食诱导肥胖 (DIO) 的小鼠模型中的肠道透性,全身炎症和脂质代谢的影响.
主要方法:
- 给C57BL/6J小鼠了15周的对照,GG补充或MPL补充的高脂肪饮食.
- 用光素异硫酸-德克斯和糖吸收测试来评估肠道透性.
- 系统性炎症,脂质新陈代谢,体质组成和肠道紧结蛋白被评估.
主要成果:
- MPL饮食增加了体内脂肪的积累,并降低了小肠的透性,但增加了结肠的透性.
- GG饮食倾向于降低肠道透率和血甘油三.
- 无论是GG还是MPL饮食都没有显著改变与脂质代谢相关的禁食葡萄糖,胰岛素耐药性,血细胞因子或肝脏基因表达.
结论:
- 饮食牛奶GG可以降低肠道透性,在DIO期间对全身炎症和脂质代谢的影响最小.
- 饮食牛奶MPL促进体脂积累,降低肠道透性,这表明牛奶极性脂在肥胖期间的代谢健康中起着不同的作用.
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