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Updated: Jun 16, 2025

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

Published on: November 29, 2024

在社区获得和COVID-19肺炎中的脂质和代谢变化

Mireia Saballs¹, Sandra Parra², Neus Martínez³

¹Internal Medicine Department, Quiron Salud Hospital, Barcelona, Spain.

Journal of lipid research

|August 18, 2024

概括

这项研究揭示了社区获得性肺炎 (CAP) 和COVID-19肺炎中鲜明的血脂和代谢物变化,突出显示了能量代谢和免疫反应的改变. 关键的差异包括COVID-19中更严重的低脂血症,以及严重病例中异位性脂蛋白和炎症标志物的共同增加.

科学领域:

生物化学生物化学
免疫学免疫学免疫学
代谢学代谢学代谢学

背景情况:

社区获得性肺炎 (CAP) 和COVID-19肺炎对全球健康构成重大挑战.
了解潜在的代谢和脂质组变化对于识别生物标志物和治疗点至关重要.

研究的目的:

为了比较患有CAP,COVID-19肺炎和健康对照患者的血脂组和代谢组.
确定与呼吸道感染和疾病严重程度相关的潜在生物标志物和代谢途径.

主要方法:

使用1H NMR光谱的前性观察研究.
对71名CAP患者,75名COVID-19肺炎患者和75名健康对照患者的血脂组和代谢组的分析.
基于疾病状态和严重程度的代谢概况的比较.

主要成果:

COVID-19 肺炎显示出比 CAP 更明显的低脂血症 (较低的总胆固醇,LDL-c) .
严重的肺炎 (两种类型) 与异位性脂蛋白 (VLDL-c,IDL-c,IDL-TG,LDL-TG/LDL-c) 的增加以及HDL-c的降低有关.
这两组感染者都表现出脂质代谢的改变 (降低化胆固醇,增加甘油三) 和减少必需脂肪酸 (DHA,omega-3).
在感染患者中观察到葡萄糖,乳酸,3-基酸,乙,分支链氨基酸和神经递质代谢物的升高.
严重的感染与谷氨胺减少和葡萄糖蛋白增加有关,这表明免疫细胞能量受损和炎症.

结论:

在CAP和COVID-19肺炎之间,新陈代谢和脂质组概况有所不同,对脂质代谢有明显的影响.
在严重的肺炎中,脂质和代谢物概况的共同变化表明与炎症,低氧化和败血症相关的常见途径.
这些发现突显了生物能途径在呼吸道感染期间调节免疫反应中的作用,并为疾病严重程度提供了潜在的生物标志物.

关键词:

在 COVID-19 疫情中,在 HDL 和 HDL 之间.这就是NMR的NMR.脂质组的类型代谢生物组的代谢生物组肺炎是一种肺炎.

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