溶解微针贴片:一种有前途的方法,可以促进通过皮肤递送抗精神分裂症药物
Qurat-Ul-Ain Umar1, Muhammad Imran Khan1, Zulcaif Ahmad1
1Riphah Institute of Pharmaceutical Sciences, Riphah International University, Lahore Campus, 54000, Lahore, Pakistan.
Journal of pharmaceutical sciences
|August 18, 2024
概括
装有氨酸 (QTP) 的溶解微针贴片 (DMNP) 已成功开发,用于增强通过皮肤递送. 这些装有QTP的DMNP表现出极好的皮肤透性,安全性和改善药物透性,为患者提供了友好的替代方案.
科学领域:
- 材料科学与工程 材料科学与工程
- 制药科学 制药科学
- 生物医学工程 生物医学工程
背景情况:
- 微针 (MNs) 提供最少的侵入性通过皮肤递送药物,绕过皮肤的屏障特性.
- 奎蒂亚平 (QTP) 是一种药物,通常需要改进的输送方法,以改善患者的服药.
研究的目的:
- 准备和表征溶解微针贴片 (DMNP) 装有提 (QTP).
- 评估DMNP在增强QTP通过皮肤传递方面的潜力.
主要方法:
- DMNP是使用溶剂造制造的,使用不同比例的聚乙醇 (PVA),聚乙烯罗利 K30 (PVP-K30) 和聚酸-合糖化物 (PLGA).
- 描述包括兼容性,厚度,插入,形态 (SEM),热分析,X射线衍射,活体透和皮肤刺激研究.
主要成果:
- 里埃变换红外光谱法 (FTIR) 证实了奎蒂亚平与微针矩阵的兼容性.
- 优化DMNP (DMNP-2) 的长度为570微米,透深度为480微米,并在皮肤插入后保持结构完整性.
- 在ex-vivo研究中,子中显示了显著的透素 (17.82μg/cm2/hr),没有观察到皮肤刺激或不良组织病理影响.
结论:
- 开发的带有提的溶解微针贴片代表了一个有前途的透皮药物递送系统.
- 这种方法提供了一种潜在的更高效,更为友好的药物管理方法,提高了对药物的遵守.
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