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两性石棉作为系统性自身免疫性疾病的环境触发因素
Jean C Pfau1, Brett McLaurin2, Brenda J Buck3
1Montana State University, Bozeman, MT, USA.
Autoimmunity reviews
|August 18, 2024
概括
与烯不同的是,两石棉暴露与人类和小鼠的狼和严重的肺部纤维化等自身免疫性疾病有关. 这凸显了人们对环境中石棉风险日益关注的公共卫生问题.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 免疫学 免疫学 免疫学
背景情况:
- 系统性自身免疫性疾病越来越多地与两类石棉暴露有关.
- 蒙大拿州的Libby Amphibole (LA) 是证据的主要来源,但意大利和澳大利亚的研究扩大了范围.
- 区分两石棉与青对于了解自身免疫性疾病风险至关重要.
研究的目的:
- 审查和总结关于两石棉暴露作为自身免疫性疾病的风险因素的当前和历史证据.
- 在驱动自身免疫病理方面,区分两石棉与青的作用.
- 为了应对环境中对石棉暴露的日益严重的公共卫生问题.
主要方法:
- 关于两石棉和自身免疫性疾病的历史和当前科学文献的综述.
- 对研究的分析,区分两石棉与青素暴露.
- 检查人类和动物 (老鼠) 研究的证据.
主要成果:
- 两石棉,但不是,诱导抗核自身抗体 (ANA) 与狼类疾病相关.
- 暴露于两类石棉会驱动对间皮细胞的致病性自身抗体.
- 这些自身抗体有助于严重的,渐进的膜纤维化.
结论:
- 两石棉是特定自身免疫性疾病和纤维性肺部疾病的重要危险因素.
- 不受监管的石棉矿物质和广泛的环境事件带来了越来越大的公共健康风险.
- 迫切需要对公众和医疗保健提供者进行教育,查和环境法规,以应对不断增加的环境石棉暴露.
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