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增加水果和蔬菜消费可以防止高脂肪饮食诱导的肥胖小鼠的免疫和炎症反应失调

Weimin Guo¹, Dayong Wu¹, Lijun Li¹

¹Nutritional Immunology Laboratory, JM USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, United States.

The Journal of nutrition

|August 18, 2024

概括

高水果和蔬菜 (F&V) 摄入量有助于预防由高脂肪饮食 (HFD) 引起的免疫系统功能障碍. 补充HFDs与F&V改善了免疫标志物,表明F&V改善了免疫标志物.

科学领域:

营养科学营养科学
免疫学免疫学免疫学
饮食干预饮食干预

背景情况:

肥胖与免疫反应减弱有关,增加感染易感性.
水果和蔬菜 (F&V) 具有抗炎性质.
有限的研究存在于F&V在减轻肥胖引起的免疫失调方面的作用.

研究的目的:

为了研究高脂肪饮食 (HFD) 中不同脂肪和维生素混合物水平对动物模型中的免疫功能的影响.
评估脏体重,脏细胞免疫表型,淋巴细胞增殖和血清细胞因子度的变化.

主要方法:

雄性C57BL/6J小鼠被食低脂肪 (LF) 饮食或HFD补充了0%,5%,10%或15%的F&V20周.
分析了脏体重,脏细胞免疫类型 (流动细胞计),脏淋巴细胞增殖 (提米丁合并) 和血清细胞因子 (Meso Scale Discovery).

主要成果:

用HFD养的小鼠显示脏重量增加,CD8+淋巴细胞减少,T淋巴细胞增殖抑制,IL-1β和IFN-γ水平降低.
在HFD中补充10%或15%的F&V可以逆转这些与肥胖相关的免疫变化.
免疫标志物和F&V摄入水平之间观察到显著的相关性.

结论:

增加F&V的消费表明对HFD诱导的免疫失调有保护作用.
结合F&V的饮食策略可能有利于在肥胖的背景下保持免疫健康.

关键词:

在CD8+淋巴细胞中.在IFN-γγ中.一个IL-1ββ.T 淋巴细胞的增殖和扩散.水果和蔬菜的果实和蔬菜有高脂肪的饮食.免疫功能免疫功能免疫功能肥胖肥胖肥胖肥胖肥胖肥胖肥胖肥胖

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