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计算机化工作记忆训练对健康个体神经可塑性的影响:一个结合的神经成像和神经递质研究

Peng Fang¹, Yuntao Gao², Yijun Li²

¹Military Medical Psychology School, Fourth Military Medical University, Xi'an, China; Shaanxi Provincial Key Laboratory of Bioelectromagnetic Detection and Intelligent Perception, Xi'an, China; Military Medical Innovation Center, Fourth Military Medical University, Xi'an, China; School of Biomedical Engineering, Fourth Military Medical University, Xi'an, China.

|August 18, 2024

概括

计算机化工作记忆训练 (WMT) 通过诱导神经可塑性来增强认知功能. 这项为期8周的干预改变了大脑活动 (ALFF) 和灰质体积 (GMV),显示出对认知增强的潜力.

科学领域:

神经科学是一个神经科学.
认知心理学认知心理学
神经成像是一种神经成像.

背景情况:

工作记忆 (WM) 对于高阶认知至关重要.
有针对性的培训干预提供了一种潜在的认知增强方法.
神经可塑性是认知改善的基础.

研究的目的:

研究8周计算机化工作记忆训练 (WMT) 方案对健康个体神经可塑性的影响.
评估WMT后大脑活动和结构的变化.
探索神经成像发现与神经递质分布之间的关系.

主要方法:

一个为期8周的计算机化工作记忆训练 (WMT) 程序.
神经成像技术包括低频波动幅度 (ALFF) 和基于声素的形态测量 (VBM).
评估灰色物质体积 (GMV) 和神经递质空间相关性 (血清素,多巴胺,NMDA).

主要成果:

WMT导致中侧上额回形中ALFF减少,而左侧中腰回形中ALFF增加.
与对照组相比,训练组在前带状皮质,角性环状回形和上叶中显示ALFF降低,在后中心环状回形中增加ALFF.
对VBM的分析显示,在训练后的右背上上额头,罗兰 operculum,前中心和后中心中GMV增加.
在神经成像指标 (ALFF,VBM) 和神经递质模式 (5-HT,DA,NMDA) 之间发现了显著的关联.

结论:

计算机化WMT诱导健康个体显著的神经塑性变化.
观察到的大脑活动和结构的改变表明WMT对认知增强的潜力.
这些发现提供了关于认知训练诱导的大脑可塑性的神经化学基础的见解.

关键词:

阿尔弗,阿尔夫,阿尔夫,阿尔夫,阿尔夫,阿尔夫,阿尔夫,阿尔夫,阿尔夫,阿尔夫,阿尔夫.计算机化工作记忆训练健康的个人健康的个人神经可塑性神经可塑性神经递质神经递质这就是VBM的VBM.

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