持续发布的3D打印布罗皮安化片,为视力受损者打印布莱尔字母
Chrystalla Protopapa1, Angeliki Siamidi1, Laura Andrade Junqueira2
1Section of Pharmaceutical Technology, Department of Pharmacy, National and Kapodistrian University of Athens, 157 84 Athens, Greece.
International journal of pharmaceutics
|August 18, 2024
概括
这项研究介绍了使用液晶显示 (LCD) 技术进行3D打印的平板电脑,用于持续释放布洛胺. 这些平板电脑为视力受损患者提供布莱尔字样图案,增强药物坚持.
科学领域:
- 制药技术 制药技术 制药技术
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
背景情况:
- 3D打印提供了个性化的剂量形式,以改善药物坚持.
- 患有视力障碍的患者需要可访问的药物信息.
研究的目的:
- 通过使用液晶三维打印来开发持续释放布洛皮安化片.
- 为视力受损患者整合布莱尔字样.
- 通过材料选择来控制药物释放率.
主要方法:
- 液晶显示器 (LCD) 3D打印的水凝油墨.
- 用聚乙烯糖醇) - 二烯酸盐 (PEGDA) 和表面活性剂进行光聚合的优化.
- 药物辅助剂相互作用和溶解概况的表征.
- 视力障碍者对布莱尔字样的验证.
主要成果:
- 成功地打印了持续释放的布洛普里昂化片,具有很高的准确性.
- 验证的盲文图案在平板电脑表面是可读的盲人患者.
- 在光聚合树脂中发现了无形状态的布鲁化.
- 通过调整PEGDA分子量和添加剂来控制布洛的溶解速率.
- 展示了液晶3D打印快速小批量生产能力.
结论:
- 液晶3D打印是一种可行的方法,可以创建个性化,可访问的药物剂量表格.
- 开发的药片可以提高视力受损患者的药物服药能力.
- 材料配方在控制药物释放动力学方面发挥着关键作用.
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