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与其他亚型相比,沉默的皮质形腺瘤表现出对状鼻,洞腔鼻和断层入侵的倾向

Alexander S Himstead¹, Alicia C Wells¹, Joshua S Kurtz¹

¹Department of Neurological Surgery, University of California, Orange, California, USA.

World neurosurgery

|August 18, 2024

概括

沉默的皮质变异性PitNETs (SCAs) 攻击性地入侵骨结构,如状鼻,鼻和洞穴鼻. 其他非功能性垂体腺瘤 (NFPAs) 通常会在上细胞空间中增长.

科学领域:

神经内分泌学神经内分泌学
神经外科神经外科
在瘤学瘤学.

背景情况:

非功能性垂体神经内分泌瘤 (PitNETs) 显示出多种不同的生长模式.
沉默的皮质形腺瘤 (SCAs) 已知具有侵略性的生长,特别是在洞穴鼻腔.
这项研究旨在将SCAs的生长模式与其他非功能性垂体腺瘤 (NFPA) 的生长模式进行比较.

研究的目的:

描述和比较沉默皮质变异性PitNETs (SCAs) 与其他非功能性垂体腺瘤 (NFPAs) 的解剖生长模式.
为了确定可能影响这些瘤类型的临床管理策略的独特的侵入性行为.

主要方法:

追溯分析91名患有非功能性PitNET的患者,这些患者接受了内镜内切除.
对手术前CT和MRI扫描的审查,以评估瘤扩展到细胞上空间,状鼻,洞腔鼻和.
使用Knosp分级 (等级3或4) 进行洞穴性鼻侵袭的分类.

主要成果:

与其他NFPA相比,静态皮质形腺瘤 (SCAs) 的侵袭率明显更高,进入状鼻 (55.0%),状鼻 (65.0%) 和洞穴鼻 (55.0%).
其他NFPA更频繁地生长到细胞上层空间 (92.96%).
瘤体积在SCAs和其他NFPA之间是可比的 (11.93cm3对比9.06cm3).

结论:

沉默的皮质变异性PitNETs表现出一种明显的倾向,侵入相邻的骨结构,包括状鼻,骨和洞穴鼻.
相比之下,其他非功能性PitNET往往会在超细胞区域内增长得更好.
这些不同的生长模式可能会导致与治疗SCAs相关的临床复杂性.

关键词:

洞穴性鼻腔 (cavernous sinus) 是一个洞穴性鼻腔.克利弗斯 (Clivus) 是一个古老的人.这是入侵的入侵.下垂体神经内分泌瘤的发生.沉默的皮质细胞增生腺瘤形鼻 (sphenoid sinus) 是一个大的部分.

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