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相关概念视频

T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

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Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
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Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment
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[与IL-18相关的自身炎症性疾病]

Philippe Mertz1, Véronique Hentgen2, Guilaine Boursier3

  • 1Sorbonne université, hôpital Tenon, DMU3ID, APHP, ERN RITA, Paris, France; Centre de référence des maladies auto-inflammatoires et de l'amylose inflammatoire (CEREMAIA), Paris, France; Centre hospitalier de Versailles, 78150 le Chesnay, France; Institut Cochin, Inserm, CNRS, université Paris Cité, F-75014 Paris, France.

La Revue de medecine interne
|August 18, 2024
PubMed
概括

与高interleukin-18 (IL-18) 相关的自身炎症性疾病 (AIDs) 涉及天生的免疫功能障碍. 测量IL-18有助于诊断和监测这些炎症状况.

关键词:
行为性病变 (Actinopathies) 是一种行为性病变.自发炎性疾病自发炎性疾病美国疾病预防控制中心42 CDC42血细胞性淋巴细胞细胞分裂.介质蛋白 18 介质蛋白 18干细胞蛋白 18 干细胞蛋白 18这是一种自发炎症性疾病.马拉迪德·斯蒂尔 (Maladie de Still) 是一个疾病.这就是PSTPIP1的原因.仍然是一种疾病.马克罗巴基失活综合征的发生.一个XIAP一个XIAP

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科学领域:

  • 免疫学 免疫学 免疫学
  • 遗传学 是一个遗传学.
  • 类风湿病学 类风湿病学

背景情况:

  • 自身炎症性疾病 (AID) 源于天生的免疫系统失调,导致全身炎症.
  • 基因组学和理解疾病机制的进步扩大了对艾滋病的研究.
  • 艾滋病的一个子集是由促进炎症的细胞因子介素-18 (IL-18) 的水平升高所定义的.

研究的目的:

  • 审查有关IL-18.8功能的文献.
  • 探索IL-18在艾滋病的诊断和治疗中的作用.
  • 确定特定的IL-18相关的艾滋病及其临床影响.

主要方法:

  • 关于IL-18和艾滋病的科学文章的文献综述.
  • 分析IL-18在免疫细胞调节和炎症通路中的作用.
  • 鉴定与IL-18相关的艾滋病相关的遗传突变和缺陷.

主要成果:

  • IL-18对于免疫细胞的增殖,生存,分化,组织透和免疫反应的两极化至关重要.
  • 与IL-18相关的艾滋病包括斯蒂尔病,NLRC4,XIAP,CDC42,PSTPIP1突变和IL-18结合蛋白缺陷.
  • 这些疾病中的大多数,除了与PSTPIP1相关的疾病,风险是巨细胞激活综合征.
  • 血清IL-18水平对于诊断,预后和监测这些疾病非常有价值.

结论:

  • IL-18是特定类型的自身炎症性疾病的关键调解剂.
  • 测量IL-18是这些疾病的宝贵诊断和监测工具.
  • 准IL-18通路为艾滋病提供了潜在的治疗策略.