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提升治疗效果的酸微封装提油和红油,使用离子凝来控制药物输送
Cengizhan Çakır1, Elif Hatice Gürkan1
1Faculty of Engineering, Chemical Engineering Department, Ondokuz Mayıs University, Kurupelit Campus, Samsun, Turkey.
Journal of biomaterials science. Polymer edition
|August 18, 2024
概括
酸微球有效地封装了治疗性西红和黄油,克服了溶解性挑战. 这些生物相容的水凝在模拟消化中显示出有前途的受控释放,增强了制药应用.
科学领域:
- 材料科学 材料科学 材料科学
- 制药科学 制药科学
- 生物技术是生物技术.
背景情况:
- 像西红和黄这样的精油具有治疗效益,但由于水溶性和不稳定性差,它面临着配方挑战.
- 酸是一种适合微封装的生物相容和生物降解聚合物,为将脂性化合物纳入制药配方提供了潜在的解决方案.
研究的目的:
- 通过离子凝,使用酸盐微球封装乳香油和黄油.
- 在模拟的消化条件下,描述开发的酸盐精油微球的物理化学特性和溶解行为.
主要方法:
- 用酸盐的离子凝技术对精油进行微封装.
- 使用富里埃变换红外光谱学 (FT-IR),扫描电子显微镜 (SEM) 和胀分析对微球进行表征.
- 确定封装效率,药物载荷能力,以及在模拟胃液 (SGF) 和模拟肠液 (SIF) 中进行体外溶解研究.
主要成果:
- 酸微球在SGF (∼15%100%) 和SIF (∼150%325%) 中呈现出显著的胀.
- 蒂油由于粘度较低,与日油相比,可以实现更高的封装效率.
- 微球表现出受控释放配置文件,溶解率为SGF中的10.98%23.56%和SIF中的52.44%63.20%.
结论:
- 酸微球是一种可行的系统,用于封装和稳定精油,提高其配方潜力.
- 离子凝方法提供了一种强大的方法,用于创建具有可调节释放特性的生物相容水凝微球.
- 这些发现表明,在制药应用中,治疗性精油的传递有增强的潜力.
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