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低血清CTRP3与2型糖尿病患者更严重的远距离对称性多神经病变有关

Pingping Han^1,2, Fan Hu¹, Jia Guo^1,2

¹Department of Endocrinology, Central Theater Command General Hospital of the Chinese PLA, Wuhan, 430070, China.

Hormones (Athens, Greece)

|August 18, 2024

概括

低血清C1q瘤坏死因子相关蛋白3 (CTRP3) 水平与2型糖尿病患者中远距离对称多神经病变 (DSPN) 的更高的患病率和严重程度有关. CTRP3可以作为DSPN发生和进展的预测因素.

科学领域:

内分泌学在内分泌学.
神经学神经学
代谢障碍代谢障碍代谢障碍

背景情况:

距离对称性多神经病变 (DSPN) 是2型糖尿病 (T2DM) 的常见并发症.
之前的研究表明,T2DM患者的血清C1q瘤缩因子相关蛋白3 (CTRP3) 水平较低.
CTRP3和DSPN流行/严重程度之间的关系需要进一步调查.

研究的目的:

调查血清CTRP3水平与T2DM患者DSPN的患病率和严重程度之间的关联.
确定CTRP3是否可以预测DSPN的发生和进展.

主要方法:

178名T2DM患者被分为DSPN (n=89) 和非DSPN (n=89) 组.
评估了人体参数,神经症状,症状,神经病症症状评分 (NSS) 和神经病症残疾评分 (NDS).
使用ELISA测量血清CTRP3,与其他生化标志物一起测量.

主要成果:

与非DSPN组相比,DSPN组的血清CTRP3水平明显较低.
CTRP3显示与积极的神经症状,NSS和NDS有负相关性.
较低的CTRP3水平 (<7.58 ng/mL) 与较高的神经症状发生率相关.
CTRP3独立预测的DSPN发生 (β = -0.316,P < 0.001) 的最佳切断值为7.55 ng/mL (AUC = 0.763).

结论:

低血清CTRP3水平与T2DM患者的DSPN患病率和严重性增加有关.
血清CTRP3可以作为T2DM中DSPN的有价值的预测生物标志物.
这些发现表明CTRP3在病变发生或作为DSPN进展标志物的潜在作用.

关键词:

C1q瘤坏死因子相关的蛋白3 (CTRP3)远距离对称性多神经病变 (DSPN)在NDS中获得得分.美国国家安全系统 (NSS) 的得分.2型糖尿病是什么? 2型糖尿病是什么?

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