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身体活动的变化及其与功能下降的关联:基于英国生物库的队列研究
Qiaoling Liu1, Carlos Celis-Morales1,2, Jennifer S Lees1
1School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
Journal of cachexia, sarcopenia and muscle
|August 19, 2024
概括
增加体力活动 (PA) 与快速功能下降的风险降低有关,特别是当通过囊素C测量时. 这强调了PA在维持健康方面的重要性.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 公共卫生 公共卫生
- 运动生理学 运动生理学
背景情况:
- 关于身体活动 (PA) 与功能之间的关系存在不一致的发现.
- 肌肉质量会影响血清肌素 (SCr) 水平,这可能会混PA对估计的膜过率 (eGFR) 的影响.
- 有限的研究已经检查了PA和功能的纵向变化.
研究的目的:
- 调查身体活动变化与功能下降速度之间的关联.
- 通过使用不同的生物标志物,探索身体活动对功能的影响.
主要方法:
- 一项使用英国生物银行数据库的队列研究.
- 身体活动变化是自我报告的代谢等效任务 (MET) 分钟/周.
- 估计的淋巴细胞过率 (eGFR) 是使用血清肌素 (SCr) 和囊素C (CysC) 来计算的.
- 考克斯和非线性回归与受限制的立方线分析了与快速功能衰退 (RDKF) 和年度eGFR变化的关联.
主要成果:
- 在PA中每周减少1000MET分钟与RDKF风险降低2%有关 (使用SCr).
- 在PA中每周增加1000MET分钟与4%的RDKF风险降低有关 (使用CysC).
- 增加的PA与0.04mL/分钟/1.73m2/年增加的eGFR相关,用CysC计算,但不用SCr.
结论:
- 根据使用的生物标志物,身体活动的变化显示出与功能变化的差异关联.
- 增加体力活动与改善年度EGFR (CysC) 和较低的快速功能下降风险有轻微联系.
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