住院住院对社区居民痴呆症患者问题药物使用的影响
W James Deardorff1,2, Bocheng Jing1,2, Matthew E Growdon1,2
1Division of Geriatrics, University of California, San Francisco, San Francisco, California, USA.
概括
住院治疗并没有显著增加痴呆症患者 (PWD) 问题药物使用. 然而,那些有较少预先存在的药物的人在住院后的处方中出现了轻微的增加.
科学领域:
- 老年学是一门学科.
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 住院影响了对痴呆症患者 (PWD) 的护理.
- 有问题的药物使用是管理痴呆症并发症的常见情况.
- 住院可能会影响出院后的药物治疗模式.
研究的目的:
- 评估住院对PWD有问题的药物处方的影响.
- 为了确定在住院后的几个月内药物使用的变化.
主要方法:
- 使用健康和退休研究数据 (2008-2018) 对于社区居住的PWD年龄≥66.
- 使用Beers标准,STOPP-V2和认知影响来定义有问题的药物.
- 医院住院前4周的药物使用与住院后4个月的药物使用相比,使用了通用线性混合模型.
主要成果:
- 总共有1,475名PWD被分析;504人有资格住院.
- 住院后观察到有问题的药物的小,非统计学意义上的增加 (1.28至1.40,p=0.12).
- 接受较少医院前慢性药物的个人 (<5) 在住院后出现问题药物的显著增加 (p=0.04对相互作用).
结论:
- 住院治疗对PWD的长期有问题的药物使用有很小的,无意义的影响.
- 某些子组,如基线药物较少的子组,可能面临更高的风险,在住院后增加有问题的处方.
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