脂溶性维生素作为营养状况的生物标志物及其与多创伤患者并发症的关系
Esmee A H Verheul1, Ebru Horzum1, Suzan Dijkink1,2
1Department of Trauma Surgery, Leiden University Medical Centre, Leiden, The Netherlands.
Nutrition and health
|August 19, 2024
概括
在接受维生素补充剂的多创伤患者中,在住院期间,维生素A,D和E的血水平增加. 这些维生素水平与营养不良或并发症无关,这表明它们不是该人口中可靠的营养生物标志物.
科学领域:
- 临床营养学 临床营养学
- 创伤护理 创伤护理
- 生物化学 生物化学
背景情况:
- 多创伤患者经常经历营养不良和并发症.
- 脂溶性维生素的状态至关重要,但在这个关键群体中没有得到充分的研究.
- 复合维生素补充剂在重症监护室 (ICU) 常见.
研究的目的:
- 在住院期间调查多创伤患者的脂溶性维生素A,D和E血水平.
- 确定这些维生素水平与营养不良和并发症的发展之间的关系.
- 评估协议化多维生素补充剂对维生素水平的影响.
主要方法:
- 49名多创伤患者的前性观察研究 (伤害严重性评分≥16).
- 在住院期间每周评估血维生素A,D和E水平.
- 使用线性混合效应模型进行趋势和后勤回归来分析与营养不良和并发症相关的统计分析.
主要成果:
- 血维生素A (0.17μmol/L),维生素D (1.49nmol/L) 和维生素E (1.17μmol/L) 水平每周显著增加.
- 这些增加归因于ICU入院期间的多种维生素补充剂.
- 维生素水平与营养不良或并发症发生率之间没有发现显著的相关性.
结论:
- 多维生素补充剂有效增加了多创伤患者的维生素A,D和E的血水平.
- 血维生素A,D和E水平不是营养状况的可靠生物标志物,也不能预测患者在住院期间会出现并发症.
- 可能需要进一步的研究来确定多创伤患者的最佳营养监测策略.
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