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在HepG2细胞中因Ivermectin引起的毒性以及四水库和维生素C的保护作用

Camila Araújo Miranda1, João Rodolfo Domingues Mansano1,2, Fábio Erminio Mingatto1

  • 1College of Agricultural and Technological Sciences, Department of Animal Science, São Paulo State University (UNESP), Dracena, Brazil.

Drug and chemical toxicology
|August 19, 2024
PubMed
概括

伊弗梅克丁 (IVM) 通过增加氧化应激会导致肝细胞损伤. 甲库尔库 (THC) 和维生素C保护HepG2细胞免受这种IVM毒性影响,这表明它们具有作为保护剂的潜力.

关键词:
它们是avermectins.罗恩斯 (RONS) 是一个抗氧化剂 抗氧化剂是一种抗氧化剂.细胞毒性 细胞毒性肝脏 肝脏 肝脏 肝脏 肝脏 肝脏线粒体中的线粒体.

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In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...