低剂量的苏芬坦尼尔在冷压器测试期间不会影响对LBNP诱导的中央低血压或血压反应的耐受性
Caitlin P Jarrard1,2, Zachary J McKenna1,3, Whitley C Atkins1,3
1Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, Texas, United States.
概括
舌下苏芬坦尼尔 (Dsuvia) 不会影响人体承受低血量的能力. 这种强大的阿片类止痛药可以减少疼痛感知,但在冷压力测试期间不会改变心血管反应.
科学领域:
- 紧急医疗 紧急医疗
- 药理学 药理学是指药理学的学科.
- 生理学 生理学 生理学
背景情况:
- 出血是医院前死亡的主要原因.
- 创伤患者的疼痛管理需要药物,以保持自主调节.
- 舌下sufentanil是一种强大的阿片类止痛药,有可能在创伤护理中使用.
研究的目的:
- 为了确定语言下苏芬坦尼尔是否会降低对中央低血压的耐受性.
- 为了评估下语言sufentanil是否减轻疼痛和心血管对有害刺激的反应.
主要方法:
- 一个双盲,随机,交叉,安慰剂对照试验,涉及29名成年人.
- 参与者接受了舌下sufentanil (30μg) 或安慰剂.
- 低体负压 (LBNP) 挑战用于低血压耐受性评估.
- 寒冷压力测试 (CPT) 用于疼痛和心血管反应评估.
主要成果:
- 在sufentanil和安慰剂试验中,对LBNP的耐受性没有显著差异.
- 在LBNP期间,静脉血压或心率变化没有显著差异.
- 苏芬坦尼尔显著减轻了CPT期间感知到的疼痛 (P < 0.001).
- 在CPT期间的平均血压反应在试验之间没有显著差异 (P = 0.078).
结论:
- 语言下用苏芬坦尼尔不会降低对进展性中央低血压的耐受性.
- 语言下使用的sufentanil有效地减少了疼痛感知.
- 对冷压器测试的心血管反应不会被舌下sufentanil减弱.
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