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丸激素和男性避孕方法
Arthi Thirumalai1, Stephanie T Page
1University of Washington, Division of Metabolism, Endocrinology and Nutrition, Seattle, Washington, USA.
Current opinion in endocrinology, diabetes, and obesity
|August 19, 2024
概括
新型荷尔蒙男性避孕药正在向市场供应方面取得进展. 雀巢/对可逆的男性避孕药有前途,满足了对男性避孕选择日益增长的需求.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 避孕的药理学 避孕的药理学
- 男人的健康 男人的健康
背景情况:
- 尽管有众多女性避孕方法,但意外怀孕率仍然很高.
- 最近对堕胎的限制强调了扩大避孕选择的必要性.
- 越来越多的男性对使用新型可逆男性避孕药越来越感兴趣.
研究的目的:
- 审查男性荷尔蒙避孕药的现状和未来前景.
- 评估新型男性避孕药配方的潜力.
- 为满足对男性避孕方法日益增长的需求.
主要方法:
- 对男性避孕药的临床研究和药物开发的审查.
- 激素机制的分析,包括雄激素和雄激素-孕激素组合.
- 通过避孕药物对下丘脑-垂体-丸轴调节的评估.
主要成果:
- 尽管经过数十年的研究,目前还没有可逆性荷尔蒙男性避孕产品.
- 雀巢/和其他新型雄激素在第三阶段研究和进入市场方面表现有前途.
- 雌激素添加到雄激素增强精子抑制,而雄激素保持eugonadism.
结论:
- 荷尔蒙男性避孕药有效抑制精子生成,通过对下丘脑-垂体-丸轴的负反.
- 对于男性避孕方案的需求和接受度显著且不断增长.
- 推进男性避孕药需要监管监督,明确的安全性/有效性标准和行业支持.
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