周围血液细胞因子和免疫检查点阻塞的结果:系统性审查和元分析
Alexander B Karol1, Yu Fujiwara2,3, Tyler D'Ovidio4
1Department of Medicine, Icahn School of Medicine at Mount Sinai, Mount Sinai Hospital, 1 Gustave L. Levy Place, New York, NY 10029, USA.
Immunotherapy
|August 19, 2024
概括
治疗前低水平的干白素-6 (IL-6) 和干白素-8 (IL-8),以及治疗期间C-反应蛋白 (CRP) 的降低,与免疫检查点阻塞治疗的更好的结果有关. 这些发现表明了治疗反应的潜在生物标志物.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 翻译医学是一种翻译医学.
背景情况:
- 促进瘤炎症和炎症性细胞因子与抵抗免疫检查点阻塞 (ICB) 有关.
- 了解特定细胞因子在ICB反应中的作用对于改善患者的治疗结果至关重要.
研究的目的:
- 为了研究治疗前和治疗期间Interleukin-6 (IL-6),Interleukin-8 (IL-8) 和C反应蛋白 (CRP) 与ICB疗效之间的关联.
- 评估这些细胞因子作为潜在的生物标志物来预测对ICB治疗的反应.
主要方法:
- 一项对27项研究的元分析,其中包括6719名接受ICB治疗的患者.
- 评估基线IL-6,IL-8水平与IL-6,IL-8和CRP在治疗过程中的变化与客观反应率 (ORR),无进展生存率 (PFS) 和整体生存率 (OS) 之间的相关性.
主要成果:
- 低的治疗前IL-6与改善的ORR,PFS和OS有关.
- 较低的治疗前IL-8水平与更好的ORR,PFS和OS相关.
- 在治疗期间CRP的下降与增强的ORR,PFS和OS有关.
结论:
- 周围血液中细胞因子水平,包括IL-6和IL-8,显示为ICB治疗的预测生物标志物具有前途.
- 治疗期间CRP的变化也可以作为药理动力学生物标志物.
- 对这些炎症标志物的进一步评估是为患者分层和针对瘤炎症的治疗策略提供保证的.
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