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相关实验视频

Updated: Jun 16, 2025

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Published on: August 8, 2022

全方位的无otropic嵌入式3D生物打印.

Lei Shao^1,2,3, Jinhong Jiang^1,3, Chenhui Yuan^1,4

¹Research Institute for Medical and Biological Engineering, Ningbo University, Ningbo, 315211, Zhejiang, China.

Materials today. Bio

|August 19, 2024

概括

这项研究引入了一种新的3D生物打印方法,使用剪切导向生物墨水来创建异型,细胞载荷的人造组织. 这种技术克服了传统水凝的局限性,使得复杂结构如血管和肌肉贴片的精确制造成为可能.

关键词:

没有异性otropy.嵌入式3D生物打印技术肌肉补丁是一个肌肉补丁.剪切面向的生物墨水.

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Last Updated: Jun 16, 2025

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Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Published on: August 8, 2022

Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer

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Published on: September 22, 2015

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Published on: May 2, 2020

科学领域:

生物材料工程生物材料工程
组织工程是组织工程.
生物打印技术的技术

背景情况:

不同类型的微观结构对于肌肉和角膜等人体组织的生理功能至关重要.
传统的水凝缺乏异性质,阻碍了复杂的,细胞载荷的异性质结构的形成.
直接嵌入式3D细胞打印为制造这种结构提供了一个有前途的方法.

研究的目的:

开发一种直接嵌入式3D生物打印系统,用于创建自由形态的异构结构.
在打印过程中利用剪切应力来定位生物油墨组件和细胞.
为了能够高精度地制造复杂的,充满细胞的无otropic 人造组织.

主要方法:

一种面向剪切的生物墨水 (GelMA/PEO) 的开发.
建立一个异型嵌入式3D生物打印系统,利用挤出产生的切削应力.
加入一个卡拉基南支浴,用于现场细胞封装和水溶性PEO去除.
制造异型血管和肌肉补丁模型.

主要成果:

通过使用剪切导向生物墨水,成功创建了具有受控细胞对齐的自由形态异型结构.
证明了复杂,多孔,异型的人造组织的高精度,单步生物打印.
通过制造异型血管和肌肉贴片来验证系统的有效性.
展示了异型肌肉补丁在细胞细胞骨架延伸方面的指导作用.

结论:

开发的异型嵌入式3D生物打印系统有效地产生带有细胞的异型组织.
这项技术克服了同otropic水凝制造复杂的异otropic结构的局限性.
该方法为异性质人造组织的ex-vivo和in-vivo应用提供了重要的基础.