在治疗神经退行性疾病时,Astragalus多糖的药理作用
1School of Basic Medical, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Frontiers in pharmacology
|August 19, 2024
概括
阿斯特拉加勒斯多糖 (APS) 显示出对阿尔茨海默氏症,帕金森症和多发性硬化症的显著神经保护作用. 这些化合物调节关键通路,减少炎症,氧化应激,促进神经元健康.
科学领域:
- 药理学和传统医学的医学.
- 神经科学是一个神经科学.
- 生物化学 生化学
背景情况:
- 阿斯特拉加勒斯膜是一种具有多样化药理作用的传统中医药.
- 关键的生物活性化合物包括黄类,素和多糖类.
- 阿斯特拉加勒斯多糖 (APS) 具有广泛的活性,如抗氧化,抗炎和神经保护作用.
研究的目的:
- 综合审查APS在神经退行性疾病中的分子机制和治疗潜力.
- 总结一下APS对阿尔茨海默病 (AD),帕金森病 (PD) 和多发性硬化症 (MS) 的影响.
主要方法:
- 文献综述侧重于APS的分子机制和治疗效果.
- 分析APS对Nrf2,JAK/STAT,Toll,IMD和PI3K/AKT/mTOR等通路的影响.
- 在神经退行模型中检查APS在调节氧化应激,炎症和细胞过程中的作用.
主要成果:
- APS改善胰岛素抵抗,降低血糖,增强认知能力,并降低AD中的Aβ积累.
- 在PD模型中,APS保护神经元,稳定线粒体,并减少氧化应激.
- 在MS模型中,APS抑制T细胞增殖,减少炎症,并促进髓再生.
结论:
- APS具有显著的抗氧化,抗炎,免疫调节和神经保护性质.
- 在治疗AD,PD和MS等神经退行性疾病方面,APS显示出相当大的治疗潜力.
- 对APS机制的进一步研究可能会导致神经系统疾病的新治疗方法.
更多相关视频
08:16Caenorhabditis elegans as a Model System for Discovering Bioactive Compounds Against Polyglutamine-Mediated Neurotoxicity
Published on: September 21, 2021
3.3K
08:27Establishment of a Valuable Mimic of Alzheimer's Disease in Rat Animal Model by Intracerebroventricular Injection of Composited Amyloid Beta Protein
Published on: July 29, 2018
11.9K
相关概念视频
01:22Alzheimer's Disease: Treatment
171
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
171
01:30Indirect-Acting Cholinergic Agonists: Pharmacological Actions
647
Indirect-acting cholinergic agonists, also known as anticholinesterases, exert their pharmacological effects by enhancing cholinergic transmission in various body parts, including the neuromuscular junction, autonomic cholinergic synapses, and the brain.
At the neuromuscular junction, these agents work by inhibiting the breakdown of acetylcholine, allowing it to remain bound to the receptor and bind to nearby receptors. This process leads to repetitive firing of the endplate, causing muscle...
At the neuromuscular junction, these agents work by inhibiting the breakdown of acetylcholine, allowing it to remain bound to the receptor and bind to nearby receptors. This process leads to repetitive firing of the endplate, causing muscle...
647
01:15Parkinson's Disease: Overview
501
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
501
01:24Parkinson's Disease: Treatment
240
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
240
01:26Alzheimer's Disease: Overview
456
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
456
01:22iPS Cell Differentiation
2.7K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
2.7K