当前和以前轮班工作对心血管风险因素,动脉样硬化和白质完整性影响的差异
David Leander Rimmele1,2, Elina L Petersen3, Sarah Affolderbach4
1Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Sleep advances : a journal of the Sleep Research Society
|August 19, 2024
概括
目前的轮班工作 (SW) 与动脉样硬化和小血管疾病标志物有关,与以前的SW不同. 这表明,持续的SW扰乱昼夜节律可能会增加神经血管风险.
科学领域:
- 神经科学是一个神经科学.
- 心血管科学 心血管科学
- 流行病学 流行病学
背景情况:
- 轮班工作 (SW) 和昼夜节律障碍被怀疑是导致心血管和脑血管疾病的因素.
- 目前与以前的SW与大动脉动脉样硬化和脑小血管疾病的标志物的特定关联仍然不清楚.
研究的目的:
- 调查当前和以前轮班工作与动脉内膜介质厚度 (CIMT) 和峰值宽骨化平均扩散率 (PSMD) 的独立关联.
主要方法:
- 汉堡城市健康研究参与者的横截面分析.
- SW定义为至少12个月的晚上6:00至早上7:00之间发生的夜班.
- 多变量回归分析使用CIMT和PSMD作为结果,根据年龄,性别和风险因素进行调整.
主要成果:
- 当前的SW与年龄和性别调整后更高的CIMT和PSMD有关.
- 当前SW和PSMD之间的关联在调整风险因素后仍然存在.
- 前SW没有与CIMT或PSMD显著关联.
结论:
- 目前的轮班工作,但不是以前的轮班工作,与大动脉动脉样硬化和大脑小血管疾病的标志物有关.
- 由于当前轮班工作而导致的昼夜节律受到干扰,可能会导致神经血管风险增加.
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