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Lisa M Arkin¹, Ana C Costa-da-Silva², Justin Frere³

¹School of Medicine and Public Health, University of Wisconsin-Madison, Department of Dermatology, Madison, WI 53726, USA.

|August 19, 2024

概括

与COVID-19大流行相关的呼吸可能是由SARS-CoV-2引发的. 局部干扰素-I信号,即使没有血清转化,也出现在一些pernio病例中,这表明病毒原因.

科学领域:

免疫学免疫学免疫学
病毒学病毒学
皮肤病学皮肤病学

背景情况:

在COVID-19大流行期间,Pernio (chilblains) 的发生率增加.
腹与干扰性疾病有关,而I型干扰素 (IFN-I) 免疫对于COVID-19恢复至关重要.

研究的目的:

调查严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 信号是否有助于与流行病相关的疾病.
为了探索IFN-I在病原发生中的作用.

主要方法:

在威斯康星州和瑞士,对患有大流行相关性腹的患者进行前性研究.
对IFN-I活性,血细胞状树突细胞和SARS-CoV-2RNA的组织活检分析.
SARS-CoV-2仓鼠感染模型,以评估病毒存在和IFN-I活性.

主要成果:

威斯康星州100%的pernio病例显示组织水平的IFN-I活性和血细胞树突细胞透.
检测到SARS-CoV-2RNA在25%的活检中从两个队列中检测到,与高度炎症相关.
受影响的患者没有对SARS-CoV-2表现出适应性免疫力.
仓鼠模型显示SARS-CoV-2 RNA和IFN-I活动在肺部和脚中,但病毒只在肺部复制.

结论:

数据支持COVID-19大流行期间的一些pernio病例的病毒触发器.
持续的局部IFN-I活性可以在没有可检测的血清转化到SARS-CoV-2的情况下发生在pernio病变中.

关键词:

细胞生物学细胞生物学免疫反应的免疫反应.免疫学免疫学免疫学

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