在腹腔透析患者的认知功能障碍查:一个横截面研究
Ana C Brás1, Joana Marques2, Vasco Fernandes2
1Department of Nephrology, Hospital Professor Doutor Fernando Fonseca, Amadora, Portugal.
Indian journal of nephrology
|August 19, 2024
概括
轻度认知障碍 (MCI) 影响了超过一半的腹腔透析 (PD) 患者,与较差的健康结果有关. 关键的危险因素包括老年,教育程度低,透析效率降低 (Kt/V,nPCR).
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 神经学 神经学
- 老年病的医生 老年病的医生
背景情况:
- 轻度认知障碍 (MCI) 是周周透析 (PD) 患者不良结果的已知危险因素,包括周周炎,技术失败和死亡率.
- 了解PD患者中MCI的患病率和风险因素对于改善患者管理和结果至关重要.
研究的目的:
- 为了确定在PD患者群体中MCI的患病率.
- 为了确定与PD患者中MCI相关的潜在风险因素.
主要方法:
- 进行了一项观察性,横截面研究.
- 用蒙特利尔认知评估 (MOCA) 和迷你精神状态检查 (MMSE) 测试来评估认知功能.
- 排除标准包括痴呆症,严重的神经功能障碍,活跃癌症或感染.
主要成果:
- 在66名PD患者 (平均年龄60岁,53%男性) 中,MCI患病率为65% (MOCA) 和33% (MMSE).
- 预测MCI的预测因素包括较高的年龄,较低的教育程度,需要助手,以及持续的门诊PD模式.
- 较高的并发症指数,冠状动脉疾病,外周动脉疾病,较低的Kt/V和较低的正常化蛋白质代谢率 (nPCR) 与MCI有关.
- 患有MCI的患者经历了更多的腹膜炎发作.
结论:
- 在PD患者中,MCI非常普遍,影响超过一半的队列.
- MCI与年龄较大,教育程度较低,疾病负担增加以及腹膜炎的风险更高有关.
- 低透析充分性 (Kt/V) 和降低的蛋白质代谢 (nPCR) 是与PD患者的MCI相关的重要因素.
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