在Streptococcus suis感染期间产生的颗粒细胞殖民地刺激因子控制血液中中性粒细胞的招募,而不会影响细菌清除
Marêva Bleuzé1, Mélanie Lehoux1, Jean-Philippe Auger1
1Research Group on Infectious Diseases in Production Animals (GREMIP) & Swine and Poultry Infectious Diseases Research Center (CRIPA), Faculty of Veterinary Medicine, University of Montreal, St-Hyacinthe, QC, Canada.
Frontiers in immunology
|August 19, 2024
概括
感染Streptococcus suis导致骨髓中大量的中性粒细胞释放,由粒细胞殖民地刺激因子 (G-CSF) 驱动. 然而,G-CSF不会影响细菌负载或炎症,这表明宿主防御中的补偿机制.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 病变的发生和发病.
背景情况:
- 瑞杆菌 (Streptococcus suis) 是一种致动物性病原体,会在猪和人类中引起严重疾病.
- 中性粒细胞动态和G-CSF在S. suis感染中的作用尚不清楚.
- 严重的炎症,败血症休克和脑膜炎是S. suis感染的标志.
研究的目的:
- 在Streptococcus suis pathogenesis中描述G-CSF-中性粒细胞轴.
- 评估在S. suis感染期间中性粒细胞的招募和激活.
- 确定G-CSF在S. suis诱导的疾病进展中的作用.
主要方法:
- 感染Streptococcus suis的小鼠模型.
- 流细胞测量用于中性粒细胞的招募和激活标志物的分析.
- 系统G-CSF水平测量和中和试验.
主要成果:
- 感染S. suis诱导了从骨髓到血液和脏的大规模中性粒细胞的招募.
- 高系统G-CSF水平与中性粒细胞招募相关.
- G-CSF中和阻断了中性粒细胞从骨髓释放,但没有影响细菌病或细胞因子风暴.
结论:
- 系统性G-CSF在S. suis感染期间驱动中性粒细胞从骨髓释放.
- G-CSF在细菌清除或炎症控制中的作用似乎被其他因素所补偿.
- 对中性粒细胞和炎症媒介作用的进一步研究对于控制S. suis感染至关重要.
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