炎症性肠病和心房动之间的关联:系统性审查和元分析
Aman Goyal1, Hritvik Jain2, Surabhi Maheshwari3
1Department of Internal Medicine, Seth GS Medical College and KEM Hospital, Mumbai, India.
患有炎症性肠病 (IBD) 的患者患上心房动 (AF) 的风险明显更高. 这一元分析证实IBD患者的风险增加了1.5倍,包括克罗恩病和性结肠炎.
科学领域:
- 胃肠病学和心脏病学
- 流行病学 流行病学
- 内部医学 内部医学
背景情况:
- 炎症性肠病 (IBD),包括克罗恩病 (CD) 和性结肠炎 (UC),涉及慢性胃肠道炎症.
- 建议IBD慢性炎症与心房 (AF) 的发展之间存在潜在联系,但缺乏强有力的证据.
研究的目的:
- 系统地评估IBD与发展AF的风险之间的关联.
- 对CD和UC患者进行关于AF风险的子组分析.
主要方法:
- 在主要数据库中对IBD患者的AF研究进行了系统的文献搜索.
- 风险比率 (RR) 和95%置信区间 (CI) 使用随机效应模型进行了聚合.
- 在p < 0.05.05时确定了统计学意义.
主要成果:
- 分析了7项涉及超过8800万患者的研究.
- 在IBD患者中,AF风险显著增加 (RR:1.52,p=0.0009).
- 亚组分析显示,UC (RR: 1.29,p=0.004) 和CD (RR: 1.30,p=0.008) 患者的AF风险增加.
结论:
- 与一般人群相比,患有IBD的人面临着患有AF的风险大幅增加.
- 分析发现了显著的异质性,强调需要大规模的前性研究来巩固这些发现.
更多相关视频
08:10Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
Published on: July 20, 2022
08:56Sterile Pericarditis in Aachener Minipigs As a Model for Atrial Myopathy and Atrial Fibrillation
Published on: September 24, 2021
相关概念视频
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...
Inflammatory Bowel Disease V: Surgical Management
Here are some common surgical interventions for IBD:
