肌性侧面硬化症的体育炼:一种潜在的辅助治疗选择,可以抵消疾病进展
Gianmarco Fenili1,2, Silvia Scaricamazza3,4, Alberto Ferri3,4
1Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", Rome, Italy.
Frontiers in cell and developmental biology
|August 19, 2024
概括
身体活动可以通过改善关键的生理途径来影响肌缩性侧面硬化症 (ALS) 的进展. 这篇评论探讨了炼运动.
科学领域:
- 神经科学和运动生理学
- 神经肌肉疾病 研究 研究 研究
背景情况:
- 肌缩侧面硬化症 (ALS) 是一种进展性神经退行性疾病,没有治愈方法.
- 身体活动在ALS病因和进展中的作用仍在争论中.
- 运动有益于涉及ALS病理学的各种生理途径.
研究的目的:
- 审查运动方案对ALS发病和进展的影响.
- 为了检查运动对人类和动物ALS模型的影响.
- 讨论运动诱导的生理反应的治疗潜力.
主要方法:
- 关于运动和ALS研究的综合文献综述.
- 对与运动干预有关的人类和动物模型数据的分析.
- 讨论将运动与ALS病理联系起来的生理机制.
主要成果:
- 身体活动可以增强骨肌肉代谢,神经发生,线粒体功能和抗氧化剂防御.
- 这些生理上的改善与ALS的发病相关.
- 有证据表明,运动可能会影响ALS的进展,尽管需要进一步的研究.
结论:
- 运动干预措施对管理ALS有潜力.
- 了解运动的生理影响可以为治疗策略提供信息.
- 需要进一步的研究来优化ALS患者的炼方案.
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