连续局部抗生素 perfusion 技术用于手术部位感染后的肩部手术
Yohei Shimada1,2, Nobuyasu Ochiai2, Eiko Hashimoto2
1Department of Orthopedic Surgery, St. Marianna University School of Medicine, Kanagawa, Japan.
JSES reviews, reports, and techniques
|August 19, 2024
概括
连续局部抗生素输液 (CLAP) 有效治疗了10名患者的肩部手术感染. 这种方法可以在没有不良事件的情况下保存组织和植入物,显示了手术部位感染管理的前景.
科学领域:
- 整形外科手术 整形外科手术
- 传染病管理 传染病管理
- 生物医学工程 生物医学工程
背景情况:
- 手术部位感染 (SSIs) 在肩部手术后具有显著的风险,可能会损害组织和植入物的完整性.
- 传统的治疗方法,如重复的手术脱bridement可能不足或不适合某些患者群体,包括老年人.
- 需要新的治疗策略来有效地管理肩膀手术患者的持续性或复杂性SSI.
研究的目的:
- 评估一种新的持续局部抗生素输液 (CLAP) 技术的疗效和安全性.
- 评估CLAP在肩部手术患者的应用,这些患者的SSI耐受常规治疗或不适合进一步手术.
- 确定CLAP在肩部手术SSI的背景下在保护组织和功能方面的潜力.
主要方法:
- 一组由10名肩部手术SSI患者组成的队列接受了CLAP,使用 gentamicin两周.
- 用CLAP治疗的患者感染不能通过重复的脱bridement控制,或对进一步的手术干预有有限的弹性.
- 监测患者的结果,包括感染控制,炎症标志物和不良事件.
主要成果:
- 持续局部抗生素输液 (CLAP) 在两周内成功控制了所有10名患者的SSI.
- 在开始CLAP后一周内,白细胞计数和C-反应蛋白水平的显著改善被观察到.
- 患者很好地忍受了CLAP治疗,在两周的输液期内没有报告任何不良事件.
结论:
- 持续局部抗生素输液 (CLAP) 在管理肩部手术SSI方面表现出高效.
- 该技术成功地保存了重要组织和骨科植入物,避免了在这个队列中需要进一步的手术干预.
- 在肩膀手术后,CLAP代表了挑战性SSI的有希望和安全的治疗选择,有可能改善患者的治疗结果.
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