拉丁美洲的多发性骨髓瘤:一个系统审查
Vania Tietsche de Moraes Hungria1, Camila Peña2, David Gómez-Almaguer3
1Discipline of Hematology and Oncology Faculdade de Ciências Médicas da Santa Casa de São Paulo São Paulo Brazil.
EJHaem
|August 19, 2024
概括
多发性骨髓瘤 (MM) 发病率在拉丁美洲因人口老龄化而上升. 尽管有可用的药物,但对 CAR-T 细胞疗法等新型治疗方法的获取有限,这阻碍了有效的MM管理.
科学领域:
- 血液学 血液学 血液学
- 流行病学 流行病学
- 在瘤学瘤学.
背景情况:
- 多发性骨髓瘤 (MM) 发病率在全球范围内不断增加,拉丁美洲国家出现了显著的激增.
- 人口老龄化和预期寿命的增加,导致MM的发病率上升.
- 了解拉丁美洲的MM流行病学对于改善患者的治疗结果至关重要.
研究的目的:
- 系统地审查一些拉丁美洲国家的多发性骨髓瘤的流行病学,患者特征和治疗结果.
- 确定该地区MM发病率,流行率和死亡率的趋势.
- 评估拉丁美洲获得新型MM疗法的挑战.
主要方法:
- 在PubMed和LILACS数据库,会议摘要和GLOBOCAN注册表 (2010-2022) 的系统文献搜索.
- 使用乔安娜·布里格斯研究所的批判性评估工具进行定性分析.
- 从586篇选的文章中,包括26篇符合特定标准的文章.
主要成果:
- 参与者的平均年龄在研究中从54岁到67岁不等.
- 巴西报告的MM发病率,流行率和死亡率最高,而乌拉圭报告的最低.
- 免疫球蛋白G是最常见的MM亚型;常见的是III期诊断. 注意到对CAR-T细胞治疗的获取有限.
结论:
- 拉丁美洲的多发性骨髓瘤发病率正在增加,需要有针对性的公共卫生战略.
- 资源限制和高成本严重阻碍了获得先进的MM疗法和新药方案的机会.
- 进一步的研究和改善医疗保健基础设施对于加强该地区MM管理和患者护理至关重要.
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