在体内,IDH2突变加速TPO诱导的髓纤维化,并增强S100a8/a9和NFκB信号传递

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Chien-Chin Lin1,2,3, Chi-Yuan Yao1,2, Yu-Hung Wang2

  • 1Department of Laboratory Medicine National Taiwan University Hospital Taipei Taiwan.

EJHaem
|August 19, 2024
PubMed
概括

异酸脱酶2 (IDH2) 突变促进炎症,并加剧骨髓纤维化 (MF) 的进展. 这项研究揭示了IDH2突变诱导的炎症作用,增加S100a8/a9水平和NFκB激活在MF.

关键词:
的IDH2突变发生.在 S100a8/a9 中,这就是TPO TPO TPO.骨髓纤维化 骨髓纤维化

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