在年轻成年人 (18-45岁) 中,CCTA引起的表心脂肪组织和冠状动脉样硬化之间的关系 (18-45岁)
Annalisa Filtz1,2, Daniel Lorenzatti1, Andrea Scotti1
1Cardiology Division, Montefiore Medical Center/Albert Einstein College of Medicine. Bronx, NY, USA.
American journal of preventive cardiology
|August 19, 2024
概括
心脂肪组织 (EAT) 体积与年轻成年人的冠状动脉疾病 (CAD) 有关. 较高的EAT量独立预测CAD的存在,建议在风险评估中使用它.
科学领域:
- 心血管成像 - 心血管成像
- 心脏病学 心脏病学
- 生物医学研究生物医学研究
背景情况:
- 副心脏脂肪组织 (EAT) 在冠状动脉疾病 (CAD) 的发展中起作用.
- 关于年轻人群体中EAT和动脉样硬化之间的关联的研究有限.
研究的目的:
- 在一个年轻的队列 (18-45岁) 中调查EAT体积和CAD之间的关系.
- 探索EAT作为对年轻成年人CAD风险评估的潜在标志物.
主要方法:
- 对712名接受冠状动脉计算机断层扫描血管造影 (CCTA) 的年轻患者的回顾性分析.
- 量化EAT体积,冠状动脉 (CAC) 和冠状动脉斑块特征.
- 使用多变量后勤回归模型来评估EAT和CAD存在之间的关联.
主要成果:
- 与没有CAD的患者相比,患有CAD的患者的EAT体积显著增加 (80.80毫升 vs 55.16毫升).
- 增加的EAT体积与CAD的存在有关,即使在没有冠状动脉的个体中 (CAC=0).
- 更高的EAT体积与更高的CAC相关,细分参与得分和斑块体积. EAT体积独立地与CAD存在相关 (OR:每10毫升1.21).
结论:
- EAT体积是年轻成年人没有疾病史的CAD的独立预测因子.
- EAT可以作为一种有价值的生物标志物,用于识别患有CAD风险的个体和治疗干预的潜在目标.
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