非高加索女性的异常性亚结节狭窄症
Amber Suk1, Salem Dehom2, Nihal Punjabi3
1School of Medicine Loma Linda University Loma Linda California USA.
OTO open
|August 19, 2024
概括
非高加索女性的异常性亚结节狭窄症 (iSGS) 与高加索女性相似,显示疾病异质性. 这项研究强调,非高加索裔ISGS患者与文献中的高加索系患者没有显著差异.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 肺部病理学 肺部病理学
- 医学研究 医学研究
背景情况:
- 异常性下狭窄症 (iSGS) 是一种罕见的疾病,影响声带下方的呼吸道.
- 大多数记录的iSGS队伍主要是白人女性,这限制了对不同人群中疾病表现的理解.
研究的目的:
- 在非高加索女性中描述iSGS的临床表现,病程和治疗.
- 为了将这一队列与现有的关于白种人占主导地位的ISGS患者人口统计学的文献进行比较.
主要方法:
- 在多家加利福尼亚机构对iSGS患者的回顾性审查 (2008-2021年).
- 排除最近输管或符合特定先前标准的患者.
- 从60个已识别的研究中对iSGS人口统计的系统审查进行比较分析.
主要成果:
- 纳入了50名患有iSGS的非高加索女性;诊断时的平均年龄为47.2岁.
- 在诊断时的疾病严重程度包括Cotton-Myer (CM) I (28.9%),CM II (40%) 和CM III (31.1%).
- 64%的患者出现复发,第一次和第二次手术之间的中位数为11个月;人口统计特征与高加索人群相似.
结论:
- 非高加索的iSGS队列,占该研究人口的近14%,与高加索队列相比,在呈现或人口统计方面没有显著差异.
- 这些发现支持iSGS患者群体中存在种族和民族异质性的存在.
- 这项研究强调了在了解和管理iSGS时需要考虑各种患者群体的必要性.
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