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Updated: Jun 16, 2025

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism
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Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism

Published on: July 28, 2017

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克服对寡核酸治疗学分析的挑战:一种新的无核对方法

Yoshiharu Hayashi1, Yuchen Sun2

  • 1Bioanalysis Research Department, CMIC Pharma Science Co., Ltd., Hyogo 677-0032, Japan.

Journal of the American Society for Mass Spectrometry
|August 19, 2024
PubMed
概括

一种新的非离子配对,逆相LC-MS方法简化了寡核酸治疗生物分析. 这种可靠,具有成本效益的方法克服了分析这些有前途的药物的传统方法的局限性.

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Ion-Exchange Chromatography01:09

Ion-Exchange Chromatography

Ion-exchange chromatography, or IEC, is a technique for separating ions based on their affinity for the stationary phase. The stationary phase is a cross-linked polymer resin with covalently attached ionic functional groups. The functional groups can be either positively charged (cation exchangers) or negatively charged (anion exchangers). A cation exchanger consists of a polymeric anion and active cations, while an anion exchanger is a polymeric cation with active anions. The choice of...
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Pore Transport and Ion-Pair Transport

Pore transport and ion-pair formation are critical mechanisms for the absorption and distribution of drugs in the body.
Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limited  but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct...
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