轻度低温治疗减弱了急性缺血性中风中的早期BBB泄漏
Yi Xu1,2, Yunxia Duan1,2, Shuaili Xu1,3
1Department of Neurology and China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China.
概括
治疗性低温 (HT) 降低了急性缺血性中风 (AIS) 转流后脑血屏障 (BBB) 泄漏. 这种细胞保护策略通过通过ROCK1/MLC途径抑制actin聚合,改善了结果.
科学领域:
- 神经科学是一个神经科学.
- 血管生物学 血管生物学
- 脑卒中研究 脑卒中研究
背景情况:
- 对急性缺血性中风 (AIS) 的再输液治疗可以矛盾地增加由于血脑屏障 (BBB) 破坏而导致的脑损伤.
- 对于辅助细胞保护性治疗来缓解反注射损伤的急需存在.
研究的目的:
- 为了研究轻度治疗性低温 (HT) 在减轻早期BBB泄漏和改善神经功能后再输血的疗效.
- 阐明HT对BBB的保护作用背后的分子机制.
主要方法:
- 使用过渡性中脑动脉封闭和再注射 (tMCAO/R) 的小鼠模型.
- 轻度的HTT在早期和重建前阶段被应用.
- 进行了大脑微血管的RNA测序和分子通路分析.
主要成果:
- 在AIS模型中,轻度HT显著减弱了早期BBB泄漏.
- 治疗HT导致心脏病发作量减少和功能神经结果改善.
- RNA测序显示HT降低了actin聚合途径的调节,特别是抑制了ROCK1/MLC信号级联.
- 作为ROCK激动剂的阿拉基酸部分逆转了HT的保护作用.
结论:
- 轻度HT的早期应用是保护BBB在缺血性中风再注射期间的一个有希望的策略.
- 通过ROCK1/MLC通路调节actin细胞骨架,HT具有细胞保护作用.
- 针对HT的血管完整性,为急性缺血性中风管理提供了一种新的治疗方法.
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