Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

16.7K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
16.7K
Experimental RNAi02:15

Experimental RNAi

6.1K
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
6.1K
Aging01:26

Aging

40
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
40
Mitochondria01:37

Mitochondria

11.7K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
11.7K
PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

3.5K
The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
3.5K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Scalable high-temperature superconducting diodes enabled by intrinsic Josephson junctions.

National science review·2026
Same author

Prioritization of molecular signatures between BDE-209-relevant targets and ulcerative colitis: a network toxicology and bioinformatics analysis.

BMC pharmacology & toxicology·2026
Same author

Cervical Dystonia with Classic Sensory Tricks and Forcible Sensory Trick Showed Different Functional Connectivity Alterations: A Functional Near-Infrared Spectroscopy Study.

Journal of clinical medicine·2026
Same author

Exploring brain activity differences in functional constipation using fNIRS: a case-control study.

Journal of neuroengineering and rehabilitation·2026
Same author

Timing of surgical excision for burn wounds: A systematic evaluation and meta-analysis comparing early and delayed excision.

The Journal of international medical research·2026
Same author

Targeting DGAT1 reprograms lipid landscape and restores CD8⁺ T cell immunity in pancreatic cancer.

Nature communications·2026

相关实验视频

Updated: Jun 16, 2025

Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

33.2K

对干扰素和细胞衰老的研究进展.

Da Wang1, Kaixian Chen1, Zheng Wang2,3

  • 1School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, P.R. China.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
|August 19, 2024
PubMed
概括
此摘要是机器生成的。

干扰素 (IFN) 在细胞衰老中起着关键作用,这是一个主要的衰老标志. 了解国际金融机构的IFN.

关键词:
身体的衰老 身体的衰老细胞衰老 细胞衰老互动互动互动互动互动.干扰子干扰子干扰子它们的作用机制.

更多相关视频

Induction and Validation of Cellular Senescence in Primary Human Cells
08:18

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

16.8K
A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
13:59

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

8.1K

相关实验视频

Last Updated: Jun 16, 2025

Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

33.2K
Induction and Validation of Cellular Senescence in Primary Human Cells
08:18

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

16.8K
A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
13:59

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

8.1K

科学领域:

  • 老年学是一门学科.
  • 免疫学 免疫学 免疫学
  • 细胞生物学 细胞生物学

背景情况:

  • 细胞衰老是衰老的一个关键标志,涉及细胞功能下降.
  • 干扰素 (IFN) 与衰老过程和衰老有关.
  • IFN信号通路的激活有助于细胞亡和衰老.

研究的目的:

  • 审查干扰素 (IFN) 和细胞衰老之间的关系.
  • 探索IFN影响细胞衰老的机制.
  • 通过针对IFN来确定延缓衰老的潜在干预措施.

主要方法:

  • 关于IFN和细胞衰老的现有研究的文献综述.
  • 分析IFN在老化相关分泌表型 (SASP) 中的作用.
  • 检查IFN对细胞亡和衰老途径的影响.

主要成果:

  • 国际金融网是SASP的一个组成部分.
  • IFN信号通路的激活与细胞亡和衰老的增加有关.
  • 通过各种机制,IFN影响细胞衰老.

结论:

  • IFN显著影响细胞衰老.
  • 针对IFN途径可能提供延迟衰老的策略.
  • 对IFN在衰老中的作用进行进一步的研究是有必要的.