图像检测动脉样硬化的流行率和特征的性别差异:基于人口的研究
Eva Swahn1,2, Sofia Sederholm Lawesson1,2, Joakim Alfredsson1,2
1Department of Cardiology, Linköping University, SE-58185 Linköping, Sweden.
European heart journal. Cardiovascular Imaging
|August 19, 2024
概括
与女性相比,男性的冠状动脉和动脉动脉样硬化患病率明显高. 动脉样硬化中的这些性别差异甚至在调整多种危险因素后仍然存在.
科学领域:
- 心血管成像 - 心血管成像
- 动脉样硬化的研究研究.
- 心血管疾病中的性别差异
背景情况:
- 心肌梗塞 (MI) 在男性中更常见.
- 在成像检测动脉样硬化中,基于人口的性别差异数据是有限的.
- 了解这些差异对于有针对性的预防战略至关重要.
研究的目的:
- 评估通过成像检测到的冠状动脉和动脉动脉样硬化的发生率的基于性别的差异.
- 在调整了各种风险因素后,研究性别和动脉样硬化之间的关联.
主要方法:
- 从瑞典心肺生物图像研究 (SCAPIS) 中,对25580名50-65岁的参与者 (50%是女性) 的横截面研究.
- 利用冠状动脉计算机断层扫描血管造影和带超声波进行综合性动脉样硬化评估.
- 任何冠状动脉样硬化,显著的冠状动脉狭窄,细分卷入得分 (SIS) ≥4,冠状动脉分数 (CACS) >100和冠状动脉斑块的评估患病率.
主要成果:
- 在所有评估的动脉样硬化指标中,男性的患病率更高:任何冠状动脉样硬化 (56.2%对29.5%),冠状动脉狭窄 ≥50% (9.0%对2.3%),SIS ≥4 (20.2%对5.3%),CACS >100 (18.2%对5.6%) 和心动脉斑 (60.9%对48.7%).
- 在男性中观察到更高的高血压,高脂血和糖尿病率.
- 多变量调整极小地改变了这些关联,男性的几率比率 (OR) 在不同动脉样硬化指标中从1.57到3.99不等.
结论:
- 与女性相比,男性的成像检测冠状动脉和动脉动脉样硬化患病率要高得多.
- 65岁女性的动脉样硬化患病率与11-13岁年轻男性的患病率相当.
- 动脉样硬化患病率的这些基于性别的差异即使对心血管风险因素进行了全面调整,仍然很大.
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