在精神分裂症患者治疗后,杏仁体子区域的变化 - 默认模式网络连接
Jianxiong Xu1, Jiaquan Liang1, Haohao Yan2
1Department of Psychiatry, The Third People's Hospital of Foshan, Foshan, Guangdong, China.
Journal of neuroscience research
|August 19, 2024
概括
精神分裂症患者表现出改变的杏仁体-默认模式网络连接. 治疗部分恢复了这些连接,特别是在右侧中枢桃体,这表明它在治疗机制中发挥了作用.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 神经成像是一种神经成像.
背景情况:
- 精神分裂症 (SCZ) 的特点是故障的默认模式网络 (DMN) 连接.
- 杏仁体在SCZ神经生物学中至关重要,其子区域可能会对疾病产生不同的影响.
研究的目的:
- 在SCZ中调查杏仁体子区域和DMN之间的功能连接 (FC).
- 探索治疗对这些杏仁核-DMN连接的影响.
主要方法:
- 休息状态功能性MRI (rs-fMRI) 在56名SCZ患者和51名健康对照 (HCs) 中.
- 杏仁体感兴趣区域 (ROI) 为FC分析分为四个部分.
- FC和临床问卷分数之间的相关性 (PANSS,RBANS5A).
主要成果:
- 治疗前:SCZ患者与HC相比,杏仁体-DMN FC有所减少.
- 治疗后:在右侧中枢桃体中仍然存在显著差异.
- 在PANSS得分和右中枢杏仁体-左SMFC FC之间发现了正相关性;RBANS5A得分和左侧杏仁体-右MTG FC之间发现了正相关性.
结论:
- 杏仁体和DMN之间的休息状态功能连接 (rsFC) 对于SCZ治疗至关重要.
- 这些联系可以作为治疗反应和神经改善机制的预测指标.
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