转移性细胞癌的治疗方法
Philipp Ivanyi1, Tabea Fröhlich, Viktor Grünwald
1Department of Hematology, Hemostaseology, Oncology and Stem Cell Transplantation, Hannover Medical School (MHH); Claudia von Schilling, Comprehensive Cancer Center Hannover; Interdisciplinary Work Group Renal Cell CarcinomaI of AUO and AIO at DKG (IAGN-DKG); West German Cancer Center, Clinic for Internal Medicine and Clinic for Urology, University Hospital Essen, Essen, Germany (AöR); Department Medical Hospital VI, University Medical Center Heidelberg, National Center for Tumor Diseases, Heidelberg; Department of Urology, Klinikum Stuttgart and Stuttgart Cancer Center - Tumor Center Eva Mayr-Stihl, Stuttgart; Urologikum Lübeck.
对转移性细胞癌 (mRCC) 的新疗法改善了生存率. 免疫检查点抑制剂 (CPI) 和铁酶抑制剂 (TKI) 等组合疗法为晚期癌患者提供了更好的结果.
科学领域:
- 在瘤学瘤学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 在德国,转移性细胞癌 (mRCC) 影响20-30%被诊断为癌的患者.
- 在历史上,对mRCC的治疗一直是缓和的,但新疗法已经出现.
- 在过去的15年里,mRCC的治疗场景发生了显著的变化.
研究的目的:
- 审查目前对转移性细胞癌 (mRCC) 的治疗策略.
- 总结新型药物治疗和局部治疗的疗效.
- 突出多学科决策在mRCC管理中的重要性.
主要方法:
- 在PubMed,ASCO和ESMO数据库中对前性研究的选择性文献搜索.
- 对细胞癌 (RCC) 的德国和欧洲瘤和泌尿学指南的审查.
主要成果:
- 药物治疗,包括免疫检查点抑制剂 (CPI) 和氨酸激酶抑制剂 (TKI) 的组合,是主要的治疗方式.
- 连续药物治疗可以实现12-24个月的无进展生存期和大约50个月的总生存期.
- 应由多学科瘤委员会考虑局部治疗,如细胞还原性腎切除术,转移切除术和放射治疗.
结论:
- 对mRCC的个性化治疗决定需要多学科的合作和专业知识.
- 当前的决策在很大程度上依赖于已确定的预后因素.
- 对于mRCC治疗的预测参数和分子标记需要进一步验证.
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