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剩余胆固醇与非酒精性脂肪性肝病之间的关联:系统性审查和元分析

Jiake Tang¹, Ting Tang¹, Qingwen Yu¹

¹Department of Cardiology, Affiliated Hospital of Hangzhou Normal University, Hangzhou Institute of Cardiovascular Diseases, Zhejiang Key Laboratory of Medical Epigenetics, Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou Normal University, Hangzhou, China.

Metabolic syndrome and related disorders

|August 19, 2024

概括

升高的残留胆固醇 (RC) 水平与非酒精性脂肪肝疾病 (NAFLD) 的更高风险有关. 这一元分析证实了RC作为一个重要的因素,敦促临床关注超越传统的风险因素.

科学领域:

心血管和代谢疾病心血管和代谢疾病
肝病学肝病学是一种肝病学.
脂质学脂质学是指脂质学.

背景情况:

脂质疾病是已知的非酒精性脂肪性肝病 (NAFLD) 风险的贡献者.
以前被忽视的残留胆固醇 (RC) 正成为NAFLD的重要,非经典风险因素.

研究的目的:

系统地评估残留胆固醇 (RC) 水平与患非酒精性脂肪肝疾病 (NAFLD) 的风险之间的关联.
通过全面的元分析,综合现有研究的证据.

主要方法:

在主要数据库 (PubMed,科学网,Embase,Cochrane图书馆,CNKI) 进行了系统的文献搜索,直到2023年8月6日.
包括回顾性队列和横截面研究,调查RC水平和NAFLD风险.
采用随机效应模型计算RC和NAFLD之间的关系的平均差异和95%置信区间.

主要成果:

在265项检索中选出的6项研究被纳入了元分析.
与非NAFLD组相比,在NAFLD组中观察到显著更高的RC水平 (MD:0.18,95%CI:0.10-0.26,P < 0.00001).
亚组分析表明,当使用弗里德瓦尔德公式 (计算方法2) 计算RC时,以及在亚洲和非亚洲人群中,无论 triglyceride 水平如何,这种关联是显著的.

结论:

升高的残留胆固醇 (RC) 水平与非酒精性脂肪肝疾病 (NAFLD) 的风险增加显著相关.
这些发现突出了RC作为NAFLD风险评估的关键生物标志物.
临床医生应该考虑监测RC水平与传统风险因素一起,以积极管理NAFLD.

关键词:

低密度脂蛋白胆固醇是低密度的脂蛋白胆固醇.这是一个元分析.非酒精性脂肪性肝病是什么?剩余的胆固醇剩余的胆固醇系统性审查系统性审查

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