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评估瘤型DX基因组前列腺评分的社会人口和区域差异

Nita H Mukand¹, Ekaterina Chirikova¹, Daphne Lichtensztajn²

¹Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA.

|August 19, 2024

概括

在瘤型DX基因组前列腺评分 (ODX-GPS) 测试的采用方面存在差异. 黑人男性和较低社会经济地位的男性使用ODX-GPS的比例较低,这凸显了对这种基因组测试的平等准入的需要.

科学领域:

在瘤学瘤学.
基因组学就是基因组学.
医疗保健服务研究医疗服务研究

背景情况:

瘤型DX基因组前列腺评分 (ODX-GPS) 是一种基因表达试验,用于预测前列腺癌的攻击性.
了解影响ODX-GPS吸收的因素对于基因组医学的公平应用至关重要.

研究的目的:

确定与局部前列腺癌男性的瘤型DX基因组前列腺评分 (ODX-GPS) 吸收相关的社会人口和区域因素.
调查在获得前列腺癌高级基因组测试方面的潜在差异.

主要方法:

监测流行病学和最终结果 (SEER) 数据分析与2013-2017年间诊断的男性的ODX-GPS结果相关联.
构建社区社会经济地位 (nSES) 五分位数和多变量后勤回归以评估ODX-GPS吸收预测因素.
包括诸如年龄,种族/种族,nSES,地区,保险,婚姻状况和国家综合癌症网络风险组等变量.

主要成果:

只有5.5%的符合条件的男性接受了ODX-GPS测试.
与其他种族群体相比,黑人男性的ODX-GPS吸收率较低 (OR 0.70).
较高的社区社会经济地位 (nSES) 和居住在东北,西部和中西部地区与增加的ODX-GPS采用有关.

结论:

根据种族,种族,社会经济地位和地理区域观察到ODX-GPS吸收的显著差异.
公平获得ODX-GPS测试至关重要,需要有针对性的干预措施.
需要进一步的研究来解决和减轻在前列腺癌的基因组测试中发现的差异.

关键词:

基因组医学是基因组医学.健康上的不平等.医疗服务的可访问性前列腺新生体前列腺瘤.健康的社会决定因素社会经济差距和健康问题

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