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血清转胺酶和老年人:分布和与所有原因死亡率的关联

Daniel Clayton-Chubb^1,2, Ammar Majeed^1,2, Stuart K Roberts^1,2

¹Department of Gastroenterology, Alfred Health, Melbourne, Victoria, Australia.

The journals of gerontology. Series A, Biological sciences and medical sciences

|August 19, 2024

概括

老年人中低氨酸氨基转移酶 (ALT) 和酸氨基转移酶 (AST) 水平与死亡风险增加有关. 具体来说,低ALT独立地增加了两性死亡风险,而低AST影响的是老年男性.

科学领域:

老年学是指老年学的学科.
临床生物化学临床生物化学
流行病学流行病学

背景情况:

氨氨基转移酶 (ALT) 和酸氨基转移酶 (AST) 是常规的临床试验.
它们的具体分布和在老年人群中的影响仍未得到充分研究.
这项研究研究了70岁及以上的个体中的这些肝酶.

研究的目的:

在老年人 (≥70岁) 中确定ALT和AST的性别分层分布.
评估ALT和AST水平与这一人口群中的死亡风险之间的关联.
确定这些关联中的潜在的性别特异性差异.

主要方法:

对阿司匹林减少老年人发作事件 (ASPREE) 试验的后期分析.
用于基线特征的单变量和多重逻辑回归.
采用考克斯回归和受限立方线来分析转氨酶水平和死亡率的联系.

主要成果:

11,853名ALT/AST水平的参与者经历了1,054起死亡,平均时间为6.4年.
男性/女性的最低五分位数是ALT:6-15/5-13 U/L和AST:8-18/7-17 U/L.
最低的ALT五分位数增加了男性 (aHR 1.51) 和女性 (aHR 1.39) 的死亡风险; 最低的AST五分位数只增加了男性的风险 (aHR 1.33).

结论:

低ALT水平是两性老年人死亡风险增加的独立预测因素.
低AST水平与增加的死亡风险有关,特别是在老年男性中.
对潜在机制的进一步研究是有必要的,目前老年人ALT正常水平的下限可能需要重新评估.

关键词:

生物化学生化学流行病学流行病学脆弱性脆弱性脆弱性肝功能肝功能肝功能

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