通过基于生理学动力学 (PBK) 模型探测到的鱼类中的imazalil和prochloraz毒动力学
Tu-Ky Ly1,2,3, Julie De Oliveira2,4, Edith Chadili2
1Experimental Toxicology and Modeling Unit, INERIS, Verneuil-en-Halatte, France.
Environmental science and pollution research international
|August 19, 2024
概括
醇杀菌剂,如普罗克洛拉兹 (PCZ) 和伊马扎利尔 (IMZ) 是水中发现的内分泌干扰剂. 这项研究开发了一种模型,以了解它们在鱼类中的毒动性行为,改善风险评估.
科学领域:
- 环境毒理学环境毒理学
- 生态毒理学 生态毒理学
- 水生毒理学 水生毒理学
背景情况:
- 亚类杀菌剂,包括prochloraz (PCZ) 和imazalil (IMZ),是经常在地表水中检测到的疑似内分泌干扰剂 (EDs).
- 关于这些化合物在鱼类中的毒动力学 (TK) 行为,知识有限,这阻碍了准确的风险评估.
研究的目的:
- 了解和建模各种鱼类物种在不同暴露路径上的PCZ和IMZ的TK.
- 开发一种基于生理学的动力学 (PBK) 模型,用于预测鱼类中这些ED的内部度和生物积累.
主要方法:
- 在PCZ和IMZ的TC上获取文献数据,并补充了对斑马鱼的新的体内实验.
- 使用贝叶斯方法 (马尔科夫链蒙特卡罗) 对三种鱼类的数据进行校准的PBK模型的开发.
- 对PBK模型的预测性能与独立实验数据的验证.
主要成果:
- PCZ和IMZ被活跃地通过鱼运输,导致吸收有限.
- 肝脏广泛地将这两种杀菌剂代谢成葡萄糖联体.
- 该PBK模型准确地预测了各物种和暴露场景中两种化合物的关键器官内的内部度,90%的数据在两倍范围内.
结论:
- 开发的PBK模型有效地描述了鱼类中PCZ和IMZ的TCK配置文件,无论暴露情况如何.
- 该模型通过预测生物积累和将分子启动事件与不良结果联系起来,有助于理解ED机制.
- 这些发现支持改善在水生生态系统中对醇杀菌剂的风险评估策略.
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