在日本的健康检查设置中开发巴雷特食道的预测得分
So Kodama1, Kenta Watanabe2, Yosuke Shimodaira1
1Department of Gastroenterology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita, 010-8543, Japan.
Esophagus : official journal of the Japan Esophageal Society
|August 19, 2024
概括
一个新的风险评分在健康检查期间识别了巴雷特食道 (Barrett's esophagus,BE) 的高风险个体,这是食道腺癌的前体. 该工具旨在通过在日本人口中检测BE来改善内镜监测.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 食道腺癌的发病率在亚洲,特别是日本正在上升.
- 巴雷特食道 (Barrett's esophagus,BE) 是一种食道腺癌的癌前症.
- 需要在一般人群中识别高风险个人进行BE查.
研究的目的:
- 在日本开发和验证巴雷特食道 (BE) 的风险预测得分.
- 通过识别面临BE高风险的个体,促进适当的内镜监测.
- 为了适应日本健康检查系统的BE风险评估.
主要方法:
- 4128名健康检查考生的回顾性招生 (2021年10月 - 2022年3月).
- 使用多变量回归模型和β回归系数开发BE预测得分.
- 内部验证评估模型歧视和校准.
主要成果:
- 为所有长度的BE开发了三个预测分数,≥1厘米和≥2厘米.
- 模型在较长的BE段中显示出优异的校准和更好的性能 (c-统计值为BE≥2cm的0.70).
- 在高风险个体中,BE ≥2cm的得分显示了52.9%的灵敏度和78.6%的特异性.
结论:
- 开发的预测得分可以通过识别有风险的个体来增强内镜检测BE.
- 这是首次针对日本人口量身定制的BE风险预测得分.
- 该得分有可能优化对BE的内镜监测策略.
相关概念视频
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